Document Detail

Comparative analysis of cell proliferation ratio in oral lichen planus, epithelial dysplasia and oral squamous cell carcinoma.
MedLine Citation:
PMID:  19680198     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Although oral lichen planus has been classified by the World Health Organization (WHO) as a potentially malignant disorder, such classification is still the target of much controversy. AIM: To evaluate the cell proliferation rate in oral lichen planus, comparing it to the rate observed in epithelial dysplasia and oral squamous cell carcinoma, aiming at indications which might indicate the potential for malignant transformation. MATERIAL AND METHODS: Twenty-four cases of each lesion were submitted to the streptoavidin-biotin and AgNOR technique to evaluate the immunohistochemical expression of PCNA and the mean NORs/nucleus, respectively. RESULTS: Positivity for PCNA was observed in 58.33% of oral lichen planus cases, 83.33% of epithelial dysplasia cases and 91.67% of oral squamous cell carcinoma cases. Chi-squared test showed that the number of positive cases for PCNA was significantly lower in oral lichen planus than in oral squamous cell carcinoma (p<0.05). No significant statistical difference between oral lichen planus and epithelial dysplasia (p>0.05) and between the epithelial dysplasia and oral squamous cell carcinoma (p>0.05) was observed. The mean NORs/nucleus in oral lichen planus, epithelial dysplasia and oral squamous cell carcinoma were 1.74+/-0.32, 2.42+/-0.62 e 2.41+/-0.61, respectively. Variance analysis (ANOVA) revealed significant statistical difference between oral lichen planus and the other studied lesions (p<0.05). CONCLUSION: Oral lichen planus cell proliferation rate was less than in oral epithelial dysplasia and oral squamous cell carcinoma which might explain the lower malignant transformation rate.
Fernando-Augusto-Cervantes-Garcia de Sousa; Tha??s-Cachut?? Paradella; Yasmin-Rodarte Carvalho; Luiz-Eduardo-Blumer Rosa
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Publication Detail:
Type:  Comparative Study; Journal Article     Date:  2009-11-01
Journal Detail:
Title:  Medicina oral, patolog??a oral y cirug??a bucal     Volume:  14     ISSN:  1698-6946     ISO Abbreviation:  Med Oral Patol Oral Cir Bucal     Publication Date:  2009 Nov 
Date Detail:
Created Date:  2009-11-02     Completed Date:  2010-02-02     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101231694     Medline TA:  Med Oral Patol Oral Cir Bucal     Country:  Spain    
Other Details:
Languages:  eng     Pagination:  e563-7     Citation Subset:  D; IM    
Department of Bioscience and Oral Diagnosis, S??o Jos?? dos Campos Dental School, S??o Paulo State University, S??o Jos?? dos Campos, SP, Brazil.
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MeSH Terms
Carcinoma, Squamous Cell / pathology*
Cell Proliferation*
Lichen Planus, Oral / pathology*
Mouth Mucosa / pathology*
Mouth Neoplasms / pathology*

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