| Comparative analysis of cell cycle regulated genes in eukaryotes. | |
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MedLine Citation:
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PMID: 16362914 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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We compared microarray experiments on cell cycle of three model eukaryotes: budding and fission yeast and human cells. Only 112 orthologous groups were cyclic in the three model organisms. The common set of cyclic orthologs includes many taking part in the cell cycle progression, like cyclin B homologs, CDC5, SCH9, DSK2, ZPR1. Proteins involved in DNA replication included histones, some checkpoint kinases and some proteins regulating DNA damage and repair. Conserved cyclic proteins involved in cytokinesis included myosins and kinesins. Many groups of genes related to translation and other metabolic processes were also cyclic in all three organisms. This reflects rebuilding of cellular components after the replication and changes of metabolism during the cell cycle. Many genes important in cell cycle control are not cyclic or not conserved. This includes transcription factors implicated in the regulation of budding yeast cell cycle. The partially overlapping roles of regulatory proteins might allow the evolutionary substitution of components of cell cycle. |
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Authors:
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Jerzy Dyczkowski; Martin Vingron |
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Publication Detail:
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Type: Comparative Study; Journal Article |
Journal Detail:
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Title: Genome informatics. International Conference on Genome Informatics Volume: 16 ISSN: 0919-9454 ISO Abbreviation: - Publication Date: 2005 |
Date Detail:
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Created Date: 2005-12-19 Completed Date: 2006-01-18 Revised Date: 2008-11-21 |
Medline Journal Info:
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Nlm Unique ID: 101280573 Medline TA: Genome Inform Country: Japan |
Other Details:
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Languages: eng Pagination: 125-31 Citation Subset: IM |
Affiliation:
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Computational Molecular Biology Department, Max Planck Institute for Molecular Genetics, Ihnestrasse 63-73, 14195 Berlin, Germany. dyczkows@molgen.mpg.de |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Computational Biology Eukaryotic Cells / physiology* Evolution, Molecular Gene Expression Regulation* Gene Expression Regulation, Fungal* Genes, Fungal* Genes, cdc* Genetic Variation Hela Cells Humans / genetics Models, Biological Oligonucleotide Array Sequence Analysis Saccharomyces cerevisiae / genetics, physiology Schizosaccharomyces / genetics, physiology |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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