| Comparative analysis of the anxiety-related behaviors in four inbred mice. | |
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MedLine Citation:
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PMID: 12426069 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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An anxiety-related behavior is an emotional response of an organism, which is quantitatively measured by several behavioral paradigms. We employed two most frequently used behavioral tests, the open field and light-dark exploration, to comparatively analyze the anxiety-like behaviors in four inbred mice. For an accurate recording of movement, motion analysis software was developed that acquires a real-time video input to generate a behavioral path. Effects of the strains on the test results were evaluated by ANOVA with the Newman-Keuls post hoc comparison. Eight different behavioral indices, four from each tests, were grouped into two classes; the results of duration, center crossing, transition, rearing, and ambulation indicate strain differences of FVB/N>C57BL/6J>/=BALB/cA>/=CBA/N (I), while stretched-attend posture, peeping, and defecation show the tendency of FVB/N=C57BL/6J<CBA/N</=BALB/cA (II). The peeping is a novel type of behavior observed in this work. Although there is a variation among behavioral indices in their discrimination between inbred lines, the behaviors are highly correlated one another such that each class I or class II behaviors are clustered on two orthogonal factor planes as a result of the principal component analysis. The polarization of each inbred line toward these two behavioral biases may reflect genetic backgrounds of these strains. |
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Authors:
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Sanghyeon Kim; Sukchan Lee; Sungho Ryu; Jea gyun Suk; Chankyu Park |
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Publication Detail:
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Type: JOURNAL ARTICLE |
Journal Detail:
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Title: Behavioural processes Volume: 60 ISSN: 1872-8308 ISO Abbreviation: Behav. Processes Publication Date: 2002 Nov |
Date Detail:
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Created Date: 2002-Nov-11 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7703854 Medline TA: Behav Processes Country: - |
Other Details:
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Languages: ENG Pagination: 181-190 Citation Subset: - |
Affiliation:
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National Creative Research Initiative Center for Behavioral Genetics, Department of Biological Sciences, Korea Advanced Institute of Science and Technology, Yusong-Ku, 305-701, Taejon, Republic of Korea |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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