Document Detail

Comparative analysis of DNA replication timing reveals conserved large-scale chromosomal architecture.
MedLine Citation:
PMID:  20617169     Owner:  NLM     Status:  MEDLINE    
Recent evidence suggests that the timing of DNA replication is coordinated across megabase-scale domains in metazoan genomes, yet the importance of this aspect of genome organization is unclear. Here we show that replication timing is remarkably conserved between human and mouse, uncovering large regions that may have been governed by similar replication dynamics since these species have diverged. This conservation is both tissue-specific and independent of the genomic G+C content conservation. Moreover, we show that time of replication is globally conserved despite numerous large-scale genome rearrangements. We systematically identify rearrangement fusion points and demonstrate that replication time can be locally diverged at these loci. Conversely, rearrangements are shown to be correlated with early replication and physical chromosomal proximity. These results suggest that large chromosomal domains of coordinated replication are shuffled by evolution while conserving the large-scale nuclear architecture of the genome.
Eitan Yaffe; Shlomit Farkash-Amar; Andreas Polten; Zohar Yakhini; Amos Tanay; Itamar Simon
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't     Date:  2010-07-01
Journal Detail:
Title:  PLoS genetics     Volume:  6     ISSN:  1553-7404     ISO Abbreviation:  PLoS Genet.     Publication Date:  2010 Jul 
Date Detail:
Created Date:  2010-07-09     Completed Date:  2010-09-01     Revised Date:  2013-05-29    
Medline Journal Info:
Nlm Unique ID:  101239074     Medline TA:  PLoS Genet     Country:  United States    
Other Details:
Languages:  eng     Pagination:  e1001011     Citation Subset:  IM    
Department of Computer Science and Applied Mathematics, Weizmann Institute of Science, Rehovot, Israel.
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MeSH Terms
Cell Line
Chromosome Mapping
Chromosomes, Mammalian / genetics*
DNA Replication Timing*
Evolution, Molecular*
Mammals / genetics*

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