| Comparative analyses of immunoglobulin genes: surprises and portents. | |
| | |
MedLine Citation:
|
PMID: 12209137 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
The study of immunoglobulin genes in non-mouse and non-human models has shown that different vertebrate groups have evolved distinct methods of generating antibody diversity. By contrast, the development of T cells in the thymus is quite similar in all of the species that have been examined. The three mechanisms by which B cells uniquely modify their immunoglobulin genes -- somatic hypermutation, gene conversion and class switching -- are increasingly believed to share some fundamental mechanisms, which studies in different vertebrate groups have helped (and will continue to help) to resolve. When these mechanisms are better understood, we should be able to look to the constitutive pathways from which they have evolved and perhaps determine whether the rearrangement of variable, diversity and joining antibody gene segments -- V(D)J recombination -- was superimposed on an existing adaptive immune system. |
| | |
Authors:
|
Martin F Flajnik |
Related Documents
:
|
9055087 - A method of estimating the numbers of human and mouse immunoglobulin v-genes. 1582417 - Enumeration and characterization of djh structures in mouse fetal liver. 11875397 - The aid enzyme induces class switch recombination in fibroblasts. 1943227 - Immunoglobulin and t-cell receptor gene rearrangements in acute non-lymphocytic leukemi... 15607427 - Dyrk gene structure and erythroid-restricted features of dyrk3 gene expression. 20359327 - Evolution of the maguk protein gene family in premetazoan lineages. |
Publication Detail:
|
Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't; Review |
Journal Detail:
|
Title: Nature reviews. Immunology Volume: 2 ISSN: 1474-1733 ISO Abbreviation: Nat. Rev. Immunol. Publication Date: 2002 Sep |
Date Detail:
|
Created Date: 2002-09-04 Completed Date: 2002-10-10 Revised Date: 2006-11-15 |
Medline Journal Info:
|
Nlm Unique ID: 101124169 Medline TA: Nat Rev Immunol Country: England |
Other Details:
|
Languages: eng Pagination: 688-98 Citation Subset: IM |
Affiliation:
|
Department of Microbiology and Immunology, University of Maryland at Baltimore, Baltimore, Maryland 21201, USA. mflajnik@som.umaryland.edu |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Animals Antibody Diversity B-Lymphocytes / immunology* Gene Conversion Gene Rearrangement, B-Lymphocyte Genes, Immunoglobulin* Humans Immunity, Active Immunoglobulin Class Switching Immunoglobulin Isotypes / chemistry, genetics*, immunology Models, Animal Translocation, Genetic |
| Chemical | |
Reg. No./Substance:
|
0/Immunoglobulin Isotypes |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Viruses and interferon: a fight for supremacy.
Next Document: Telomeres in T and B cells.