Document Detail


Comparative adverse cardiac effects of pimobendan and benazepril monotherapy in dogs with mild degenerative mitral valve disease: a prospective, controlled, blinded, and randomized study.
MedLine Citation:
PMID:  17708394     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: Pimobendan (PIMO) is an inodilator that may have some beneficial effects in canine degenerative mitral valve disease (MVD). However, little information is available about its cardiac effects in dogs without systolic myocardial dysfunction. HYPOTHESIS: Compared to benazepril (BNZ), an angiotensin-converting enzyme inhibitor, PIMO may worsen valve regurgitation in early canine MVD. ANIMALS: Twelve Beagles with asymptomatic MVD were randomized into 2 groups (n = 6) receiving BNZ or PIMO at dosages of 0.25 mg/kg PO q24h and q12h respectively, for 512 days. METHODS: The study followed a blinded, randomized, prospective, and parallel group design. After day 512, the dogs were necropsied, and cardiac histopathology was performed in a blinded manner. RESULTS: A significant treatment effect was observed as soon as day 15 with increased systolic function in the PIMO group by comparison to baseline value as assessed by fractional shortening (P < .0001) and tissue Doppler variables (P = .001). Concurrently, the maximum area and peak velocity of the regurgitant jet signal increased (P < .001), whereas these variables remained stable in the BNZ group. Histologic grades of mitral valve lesions were more severe in the PIMO group than in the BNZ group. Moreover, acute focal hemorrhages, endothelial papillary hyperplasia, and infiltration of chordae tendinae with glycosaminoglycans were observed in the mitral valves of dogs from the PIMO group but not in those of the BNZ group. CONCLUSIONS AND CLINICAL IMPORTANCE: PIMO has adverse cardiac functional and morphologic effects in dogs with asymptomatic MVD. Additional investigation in dogs with symptomatic MVD is now warranted.
Authors:
Valérie Chetboul; Hervé P Lefebvre; Carolina Carlos Sampedrano; Vassiliki Gouni; Vittorio Saponaro; François Serres; Didier Concordet; Audrey P Nicolle; Jean-Louis Pouchelon
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Publication Detail:
Type:  Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of veterinary internal medicine / American College of Veterinary Internal Medicine     Volume:  21     ISSN:  0891-6640     ISO Abbreviation:  J. Vet. Intern. Med.     Publication Date:    2007 Jul-Aug
Date Detail:
Created Date:  2007-08-21     Completed Date:  2007-09-20     Revised Date:  2008-09-22    
Medline Journal Info:
Nlm Unique ID:  8708660     Medline TA:  J Vet Intern Med     Country:  United States    
Other Details:
Languages:  eng     Pagination:  742-53     Citation Subset:  IM    
Affiliation:
Unité de Cardiologie d'Alfort, Ecole Nationale Vétérinaire d'Alfort, 7 Avenue du Général de Gaulle, 94 704 Maisons-Alfort, France. vchetboul@vet-alfort.fr
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MeSH Terms
Descriptor/Qualifier:
Animals
Benzazepines / adverse effects*,  therapeutic use*
Blood Pressure / drug effects
Body Weight / drug effects
Dog Diseases / drug therapy*
Dogs
Double-Blind Method
Echocardiography / drug effects,  veterinary
Mitral Valve Insufficiency / drug therapy,  veterinary*
Myocardium / pathology
Pyridazines / adverse effects*,  therapeutic use*
Time Factors
Chemical
Reg. No./Substance:
0/Benzazepines; 0/Pyridazines; 74150-27-9/pimobendan; 86541-75-5/benazepril
Comments/Corrections
Comment In:
J Vet Intern Med. 2008 Mar-Apr;22(2):243; author reply 245   [PMID:  18371020 ]
J Vet Intern Med. 2008 Mar-Apr;22(2):243-4; author reply 245-6   [PMID:  18371019 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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