| Comparative acute toxicities and immunomodulatory potentials of five Eastern Nigeria mistletoes. | |
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MedLine Citation:
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PMID: 19703540 Owner: NLM Status: In-Process |
Abstract/OtherAbstract:
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ETHNOPHARMACOLOGICAL RELEVANCE: Traditionally, mistletoes of Eastern Nigeria origin, Loranthus micranthus Linn. have been used as immunostimulant for the management of certain diseases with high profile immune depleting potentials. This practice has remained till date without scientific validation. AIM OF STUDY: To obtain and validate evidence for or against its continued use as immunostimulant and afford data for further studies on this specie of mistletoe. The present work is an in vivo proof of ethnopharmacological concept of the age long immunomodulatory use of our local mistletoe. MATERIALS AND METHODS: Aqueous-methanol extracts of the plant leaves from five different host trees were evaluated for immunomodulatory activity using four in vivo models in mice or rats, namely; total and differential leukocyte count (TLC and DLC), the cellular mediated delayed-type hypersensitivity reaction (DTHR) test, the humoral mediated antibody titration (AT) test and the cyclophosphamide-induced myelosuppression (CIM) test at different dose levels (100, 200 and 400 or 50, 100 and 250 mg kg(-1); depending on model) against standard controls. Phytochemical and acute toxicity tests were equally carried out on all the extracts. RESULTS: Results obtained indicate that all the mistletoes contained the same phytochemical constituents, although in varying amounts. The mistletoes exhibited statistically significantly different (p < 0.05 or p < 0.001, ANOVA) immunomodulatory (up-regulatory) activities in the overall order of that from Kola acuminata > Citrus spp > Persia americana > Parkia biglobosa > Pentaclatra macrophylla. LD(50) values were generally greater than 5000 mg/kg. CONCLUSION: The present study confirms the Eastern Nigeria mistletoe as a potent and safe alternative or complementary medicine for the management of immunodeficiency diseases. |
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Authors:
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Patience Ogoamaka Osadebe; Edwin Ogechukwu Omeje |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2009-08-22 |
Journal Detail:
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Title: Journal of ethnopharmacology Volume: 126 ISSN: 1872-7573 ISO Abbreviation: J Ethnopharmacol Publication Date: 2009 Nov |
Date Detail:
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Created Date: 2009-11-02 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7903310 Medline TA: J Ethnopharmacol Country: Ireland |
Other Details:
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Languages: eng Pagination: 287-93 Citation Subset: IM |
Affiliation:
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Department of Pharmaceutical and Medicinal Chemistry, Faculty of Pharmaceutical Sciences, University of Nigeria, 410001 Nsukka, Enugu State, Nigeria. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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