Document Detail


Comparative activity of natural mono-, di- and tri-hydroxy derivatives of arachidonic acid on guinea-pig lungs: myotropic effect and stimulation of cyclooxygenase activity.
MedLine Citation:
PMID:  6296925     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The activity of natural 5,6-Dihydroxy-eicosatetraenoic acid (5,6-DiHETE; 2 isomers), 5S,15S-DiHETE, 8S,15S-DiHETE, 5S,12S-DiHETE, delta 6-trans-leukotriene B4, 12-epi-delta 6-trans-leukotriene B4, omega-hydroxy-leukotriene B4, omega-carboxy-leukotriene B4, 15S-hydroxyeicosatetraenoic acid (15S-HETE), 12S-HETE, 5S-HETE and 12S-hydroxy-heptadecatrienoic acid was compared to LTB4 on the guinea-pig lung parenchymal strip and on the release of prostaglandins and thromboxanes by the perfused guinea-pig lungs. The omega-hydroxy-LTB4 appeared more potent than LTB4 both for inducing a contraction and for releasing prostanoids whereas the omega-carboxy-LTB4 was much less active on the parenchyma and did not release prostanoids at the dose used. All other hydroxy acids tested were either very weakly active or inactive in the two systems used with the exception of the 5,6-DiHETEs which showed significant activity. These di-hydroxy acids induced contractions of the lung parenchymal strip which could be blocked by FPL-55712 but were inactive on the guinea-pig ileum. The 5S-HETE, 12S-HETE and 15S-HETE were also tested for possible myotropic activity on selected smooth muscle preparations. Our results provide further informations on the structural requirements for LTB4 (and other hydroxy acids) actions on the guinea-pig lungs.
Authors:
P Sirois; S Roy; G Beraldin; P Vallerand; P Borgeat
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Prostaglandins     Volume:  24     ISSN:  0090-6980     ISO Abbreviation:  Prostaglandins     Publication Date:  1982 Sep 
Date Detail:
Created Date:  1983-03-11     Completed Date:  1983-03-11     Revised Date:  2005-11-17    
Medline Journal Info:
Nlm Unique ID:  0320271     Medline TA:  Prostaglandins     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  405-18     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
12-Hydroxy-5,8,10,14-eicosatetraenoic Acid
Animals
Arachidonic Acids / pharmacology*
Dose-Response Relationship, Drug
Guinea Pigs
Hydroxyeicosatetraenoic Acids*
Isomerism
Leukotriene B4 / pharmacology*
Lung / drug effects*
Prostaglandin-Endoperoxide Synthases / metabolism*
Chemical
Reg. No./Substance:
0/Arachidonic Acids; 0/Hydroxyeicosatetraenoic Acids; 59985-28-3/12-Hydroxy-5,8,10,14-eicosatetraenoic Acid; 71160-24-2/Leukotriene B4; 72255-35-7/5-hydroxy-6,8,11,14-eicosatetraenoic acid; EC 1.14.99.1/Prostaglandin-Endoperoxide Synthases

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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