Document Detail

Comparative activities of cefotaxime, a new cephalosporin derivative, and of selected beta-lactam antibiotics against Haemophilus species.
MedLine Citation:
PMID:  315745     Owner:  NLM     Status:  MEDLINE    
The activity of cefotaxime (HR756), a new semi-synthetic cephalosporin, was compared with the activity of ampicillin, carbenicillin, cephalothin, cephaloridine, cefazolin, cefamandole and cefoxitin against 247 strains of Haemophilus sp.; 20 of these strains produce a beta-lactam inactivating enzyme. The minimal inhibitoring concentrations were determined by the agar plate dilution technique. Cefotaxime is not only more active than any other cephalosporin but also than ampicillin, generally estimated the most active drug against Haemophilus sp. Bacteriostatic concentrations of cefotaxime which inhibit 50 and 95% of the strains (BSC50 and BSC95) were 0,009 microgram/ml and 0,03 microgram/ml, respectively, showing an activity 20 times superior to that of ampicillin. Cefotaxime activity was unaffected by the production of beta-lactamase.
H J Dabernat; A Buu-Hoï-Dang Van; C Delmas; R Bauriaud
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Annales de microbiologie     Volume:  130 A     ISSN:  0300-5410     ISO Abbreviation:  Ann. Microbiol. (Paris)     Publication Date:    1979 May-Jun
Date Detail:
Created Date:  1980-01-19     Completed Date:  1980-01-19     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0354704     Medline TA:  Ann Microbiol (Paris)     Country:  FRANCE    
Other Details:
Languages:  eng     Pagination:  461-7     Citation Subset:  IM    
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MeSH Terms
Ampicillin / pharmacology*
Carbenicillin / pharmacology*
Cephalosporins / pharmacology*
Haemophilus / drug effects*,  enzymology
Microbial Sensitivity Tests
Penicillin Resistance
beta-Lactamases / metabolism
Reg. No./Substance:
0/Cephalosporins; 4697-36-3/Carbenicillin; 69-53-4/Ampicillin; EC

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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