Document Detail

Comparative actions of adrenomedullin and nitroprusside: interactions with ANG II and norepinephrine.
MedLine Citation:
PMID:  11705774     Owner:  NLM     Status:  MEDLINE    
The role of adrenomedullin (ADM) in volume and pressure homeostasis remains undefined. Accordingly, we compared the biological responses to infusions of ADM and nitroprusside (NP; matched for reduction of arterial pressure) and assessed their effects on responses to ANG II and norepinephrine in eight conscious sheep. During matched falls in arterial pressure (8-10 mmHg, both P < 0.001) ADM and NP induced similar increases in heart rate. ADM increased cardiac output (P < 0.001), and the fall in calculated peripheral resistance was greater with ADM than NP (P = 0.013). ADM infusions raised plasma ADM levels (P < 0.001), plasma renin activity (P = 0.001), and ANG II (P < 0.001) but tended to blunt any concurrent rise in aldosterone compared with NP (P = 0.056). ADM maintained both urine flow (P < 0.001) and sodium excretion (P = 0.01) compared with falls observed with NP. ADM attenuated the vasopressor actions of exogenous ANG II (P = 0.006) but not norepinephrine. In addition, ADM antagonized the ANG II-induced rise in plasma aldosterone (P < 0.001). In conclusion, ADM induces a different spectrum of hemodynamic, renal, and endocrine actions to NP. These results clarify mechanisms by which ADM might contribute to volume and pressure homeostasis.
C J Charles; M G Nicholls; M T Rademaker; A M Richards
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  American journal of physiology. Regulatory, integrative and comparative physiology     Volume:  281     ISSN:  0363-6119     ISO Abbreviation:  Am. J. Physiol. Regul. Integr. Comp. Physiol.     Publication Date:  2001 Dec 
Date Detail:
Created Date:  2001-11-13     Completed Date:  2002-01-02     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  100901230     Medline TA:  Am J Physiol Regul Integr Comp Physiol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  R1887-94     Citation Subset:  IM    
Cardioendocrine Research Group, Christchurch School of Medicine, PO Box 4345, Christchurch, New Zealand.
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MeSH Terms
Angiotensin II / metabolism*
Atrial Natriuretic Factor / metabolism
Blood Pressure / drug effects
Cardiac Output / drug effects
Creatinine / metabolism,  urine
Endothelins / blood
Heart Rate / drug effects
Hemodynamics / drug effects*,  physiology
Homeostasis / drug effects,  physiology
Natriuretic Peptide, Brain / blood
Nitroprusside / pharmacology*
Norepinephrine / blood*
Peptides / pharmacology*
Potassium / blood
Renin-Angiotensin System / drug effects
Reg. No./Substance:
0/Endothelins; 0/Peptides; 11128-99-7/Angiotensin II; 114471-18-0/Natriuretic Peptide, Brain; 148498-78-6/Adrenomedullin; 15078-28-1/Nitroprusside; 51-41-2/Norepinephrine; 60-27-5/Creatinine; 7440-09-7/Potassium; 85637-73-6/Atrial Natriuretic Factor

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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