Document Detail


Comparative X-ray structure analysis of human and Escherichia coli tRNA(Gly) acceptor stem microhelices.
MedLine Citation:
PMID:  18275849     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
tRNA identity elements assure the correct aminoacylation of tRNAs by the aminoacyl-tRNA synthetases with the cognate amino acid. The tRNA(Gly)/glycyl-tRNA sythetase system is member of the so-called 'class II system' in which the tRNA determinants consist of rather simple elements. These are mostly located in the tRNA acceptor stem and in the glycine case additionally the discriminator base at position 73 is required. Within the glycine-tRNA synthetases, the archaebacterial/human and the eubacterial sytems differ with respect to their protein structures and the required tRNA identity elements, suggesting a unique evolutionary divergence. In this study, we present a comparison between the crystal structures of the eubacterial Escherichia coli and the human tRNA(Gly) acceptor stem microhelices and their surrounding hydration patterns.
Authors:
C Förster; A Zerressen-Harte; J P Fürste; M Perbandt; Ch Betzel; V A Erdmann
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't     Date:  2008-02-12
Journal Detail:
Title:  Biochemical and biophysical research communications     Volume:  368     ISSN:  1090-2104     ISO Abbreviation:  Biochem. Biophys. Res. Commun.     Publication Date:  2008 Apr 
Date Detail:
Created Date:  2008-03-10     Completed Date:  2008-03-31     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0372516     Medline TA:  Biochem Biophys Res Commun     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1002-6     Citation Subset:  IM    
Affiliation:
Institute of Chemistry and Biochemistry, Free University Berlin, Thielallee 63, 14195 Berlin, Germany.
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MeSH Terms
Descriptor/Qualifier:
Escherichia coli / genetics*
Glycine-tRNA Ligase / chemistry*
Humans
Models, Molecular
Nucleic Acid Conformation
RNA, Transfer, Gly / chemistry*
Water / chemistry
Chemical
Reg. No./Substance:
0/RNA, Transfer, Gly; 7732-18-5/Water; EC 6.1.1.14/Glycine-tRNA Ligase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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