| Comparative value of NYHA functional class and quality-of-life questionnaire scores in assessing heart failure. | |
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MedLine Citation:
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PMID: 19952769 Owner: NLM Status: In-Process |
Abstract/OtherAbstract:
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PURPOSE: To assess the relationships between New York Heart Association (NYHA) functional class, quality of life, aerobic capacity (peak oxygen uptake, (.)VO2), ventilatory efficiency (minute ventilation/carbon dioxide production slope, VE/(.)VCO2 slope), and brain natriuretic peptide (BNP) in creating a model for predicting peak (.)VO2). METHODS: Cardiopulmonary exercise testing was performed in 62 patients. A baseline blood sample was taken to measure the N-terminal prohormone BNP (NT-proBNP). Patients also completed the Minnesota Living with Heart Failure Questionnaire (MLHF) and the Specific Activity Questionnaire (SAQ), and NYHA functional class was determined. RESULTS: NYHA functional class correlated more strongly with SAQ score than with MLHF score. Peak (.)VO2 and VE/(.)VCO2 slope had stronger associations with NYHA functional class and SAQ score than with MLHF score. NT-proBNP plasma levels correlated more significantly with NYHA functional class and SAQ score (both P < .001) than with MLHF score. Using multiple linear regression analysis adjusted for age and sex, SAQ score, NT-proBNP, and etiology of heart failure had significant independent relationships with peak (.)VO2, explaining 63% of its variability (adjusted R(2) = 0.596). CONCLUSIONS: Cardiopulmonary exercise variables and plasma NT-proBNP are associated more with NYHA functional class and SAQ score than with MLHF score. When combined, SAQ score, NT-proBNP, and etiology of heart failure can satisfactorily predict peak oxygen uptake. |
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Authors:
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Leonidas V Athanasopoulos; Athanasios Dritsas; Helen A Doll; Dennis V Cokkinos |
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Publication Detail:
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Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Journal of cardiopulmonary rehabilitation and prevention Volume: 30 ISSN: 1932-751X ISO Abbreviation: J Cardiopulm Rehabil Prev Publication Date: 2010 Mar-Apr |
Date Detail:
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Created Date: 2010-03-10 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101291247 Medline TA: J Cardiopulm Rehabil Prev Country: United States |
Other Details:
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Languages: eng Pagination: 101-5 Citation Subset: IM |
Affiliation:
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1st Cardiology Department, Onassis Cardiac Surgery Center, Athens, Greece. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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