| Comparative study of ropivacaine 0.5% and levobupivacaine 0.33% in axillary brachial plexus block. | |
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MedLine Citation:
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PMID: 19920417 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: The aim of this prospective, randomized, double-blind study was to compare the block induced by ropivacaine 0.5% with levobupivacaine 0.33% at the recommended dose range in upper limb surgery. These concentrations have provided equivalent block after epidural analgesia. We hypothesized that the block induced by both local anesthetics at clinical equipotent dose would be similar in axillary block. METHODS: Eighty-six patients received 30 mL of ropivacaine 0.5% (150 mg) or 30 mL of levobupivacaine 0.33% (99 mg) by axillary approach. Sensory and motor blocks were assessed in the 5 main nerve territories of the arm at 2, 5, 10, 15, 20, 25, and 30 mins and every 6 hrs for the first 24 hrs. We used the Student t test and chi test for comparison between groups and an analysis of survival. P < 0.05 was considered statistically significant. RESULTS: Onset of motor block was 9.0 mins (SD, 5.3 mins) for ropivacaine and 12.4 mins (SD, 7.8 mins) for levobupivacaine (P = 0.02). Time to be considered ready for surgery was similar in both groups: ropivacaine, 25.2 mins (SD, 5.1 mins); and levobupivacaine, 25.3 mins (SD, 6.4 mins) (t = -0.09, P = 0.93). Sensory block was 9.2 hrs (SD, 3.1 hrs) for ropivacaine and 11.3 hrs (SD, 4.1 hrs) for levobupivacaine (P = 0.01). CONCLUSIONS: Onset of motor block was significantly faster for ropivacaine than levobupivacaine (P = 0.02), but the time to be ready for surgery was similar with both drugs. Duration of sensory block was prolonged with levobupivacaine (P = 0.01). |
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Authors:
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Susana Gonz??lez-Su??rez; Mauricio Pacheco; Jaume Roig??; Margarita M Puig |
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Publication Detail:
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Type: Comparative Study; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Regional anesthesia and pain medicine Volume: 34 ISSN: 1532-8651 ISO Abbreviation: Reg Anesth Pain Med Publication Date: 2009 Sep-Oct |
Date Detail:
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Created Date: 2009-11-20 Completed Date: 2010-01-27 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9804508 Medline TA: Reg Anesth Pain Med Country: United States |
Other Details:
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Languages: eng Pagination: 414-9 Citation Subset: IM |
Affiliation:
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Department of Anaesthesiology, Hospital Universitario de la Vall d'Hebr??n, Universitat Aut??noma de Barcelona, Barcelona, Spain. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Amides / administration & dosage* Analgesics / therapeutic use Anesthetics, Local / administration & dosage* Brachial Plexus / drug effects* Bupivacaine / administration & dosage, analogs & derivatives Double-Blind Method Female Humans Injections Male Middle Aged Motor Activity / drug effects Nerve Block* Pain Measurement Pain, Postoperative / prevention & control Prospective Studies Sensory Thresholds / drug effects Time Factors Upper Extremity / surgery |
| Chemical | |
Reg. No./Substance:
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0/Amides; 0/Analgesics; 0/Anesthetics, Local; 0/levobupivacaine; 2180-92-9/Bupivacaine; 84057-95-4/ropivacaine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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