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A Comparative Study of Root Defect Coverage Using an Acellular Dermal Matrix With and Without a Recombinant Human Platelet Derived Growth Factor.
MedLine Citation:
PMID:  22149763     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Background: The objective of this study was to compare root defect coverage results and healing responses of bilateral recession defects treated with acellular dermal matrix with and without recombinant human platelet derived growth factor. Methods: Seventeen patients with 40 bilateral gingival recession defects were compared. Each defect was 2 mm or greater and treated with acellular dermal matrix (ADM) and a coronally advanced flap (CAF). Using split-mouth design, control side ADM was hydrated in sterile saline while test side ADM was hydrated in recombinant human platelet derived growth factor (rhPDGF). The patients were evaluated at 1 week, 1 month, 3 months and 6 months. Standardized measurements were taken preoperatively, at 3 months and 6 months. Healing was clinically assessed at 1 week and 1 month post-surgically. Results: Both test and control groups showed significant gain in root defect coverage over the 6 month period for all subjects with the test group showing a 69.0% gain and the control group showing a 76.7% gain. Subjects divided into Miller Class I and Miller Class III defects were also found to have a significant gain in root defect coverage over 6 months. The test group showed 84.1% gain and the control group showed 84.7% gain for Miller Class I defects. For Miller Class III defects, the test group showed 51.5% gain and the control group showed a 60.8% gain. One week after surgery, 35% of the test group showed better healing while 15% of the control group showed better healing. One month after surgery, 20% of the test group showed better healing while 15% of the control group showed better healing. Conclusions: Based on the results of this study, there were no statistically or clinically significant differences in root defect coverage, keratinized tissue, probing attachment level, or clinical healing for treatment of root recession with a coronally advanced flap and ADM with and without rhPDGF.
Authors:
Christopher M Carney; Jeffrey A Rossmann; David G Kerns; Daisha J Cipher; Terry D Rees; Eric S Solomon; Francisco Rivera-Hidalgo; M Miles Beach
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-12-8
Journal Detail:
Title:  Journal of periodontology     Volume:  -     ISSN:  1943-3670     ISO Abbreviation:  -     Publication Date:  2011 Dec 
Date Detail:
Created Date:  2011-12-13     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8000345     Medline TA:  J Periodontol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
Department of Periodontics, Texas A&M University Health Science Center, Baylor College of Dentistry, Dallas, TX.
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