Document Detail

A Comparative Study of Histopathological Analysis of Filum Terminale in Patients with Tethered Cord Syndrome and in Normal Human Fetuses.
MedLine Citation:
PMID:  22776912     Owner:  NLM     Status:  Publisher    
Background: The structural changes in filum terminale (FT) may be responsible for tethered cord syndrome (TCS) in children. Although the histological changes in FT related to TCS are well-known, there is no comparative study of the changes which occur in TCS and normal fetal FT samples. The aims of this study are to compare the histological changes which occurred in FT samples of TCS and in fetuses, and to point out these changes. Methods: During the last 2 years, 14 cases of TCS were operated on, the FT was cut and the spinal cord was released. Among them, 6 samples of FT were obtained for histopathological examination. Moreover, 1 FT from an adult cadaver and 4 samples from fetal FT were obtained for the same examination. Results: While adipose tissue, fibrosis, hyalinization, and meningothelial proliferation were observed in FT samples of TCS, none of these findings were observed in fetal samples. Elastic fibers were present in all TCS specimens and the adult cadaver, but were not observed in fetuses. Peripheral nerves, ganglion cells and ependymal cells were observed in fetal FT samples. Conclusion: These changes probably begin at birth.
Ozkan Tehli; Irgen Hodaj; Cahit Kural; Ilker Solmaz; Onder Onguru; Yusuf Izci
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-7-07
Journal Detail:
Title:  Pediatric neurosurgery     Volume:  47     ISSN:  1423-0305     ISO Abbreviation:  -     Publication Date:  2012 Jul 
Date Detail:
Created Date:  2012-7-10     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9114967     Medline TA:  Pediatr Neurosurg     Country:  -    
Other Details:
Languages:  ENG     Pagination:  412-416     Citation Subset:  -    
Copyright Information:
Copyright © 2012 S. Karger AG, Basel.
Department of Neurosurgery, Gulhane Military Medical Academy, Etlik, Turkey.
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