| A Comparative Study of Gastric Banding and Sleeve Gastrectomy in an Obese Diabetic Rat Model. | |
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MedLine Citation:
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PMID: 21874366 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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BACKGROUND: Laparoscopic sleeve gastrectomy (SG) is now a typical restrictive bariatric procedure. The aim of this study was to evaluate the efficacy of SG in comparison with gastric banding (GB) in an obese diabetic rat model. METHODS: Forty-five male Zucker diabetic fatty rats were divided into three groups: sham-operated (SO) control, GB, and SG. The rats were followed for 6 weeks after surgery, and their body weight change, cumulative food intake, metabolic parameters, plasma levels of ghrelin, glucagon-like peptide-1 and adiponectin, oral glucose tolerance test (OGTT), insulin tolerance test (ITT), and gastric emptying rate were measured. RESULTS: The GB and SG groups showed significant decreases in weight, cumulative intake, and metabolic parameters and significant improvement of OGTT and ITT results compared with the SO group. There were no significant differences in weight and cumulative food intake between the groups. However, the SG group showed significantly higher gastric emptying rate and plasma level of adiponectin and lower plasma levels of free fatty acid, total cholesterol, and ghrelin compared with the GB group. Furthermore, the SG group showed improvement of OGTT and ITT results in comparison with the GB group. CONCLUSIONS: In obese diabetic rats, SG may improve glucose and lipid metabolism compared with GB, although there was no significant difference in the effect on body weight loss between the two procedures. The hormonal and digestive changes induced by SG may have relevance to the effects on metabolism. |
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Authors:
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Takashi Masuda; Masayuki Ohta; Teijiro Hirashita; Yuichiro Kawano; Hidetoshi Eguchi; Kazuhiro Yada; Yukio Iwashita; Seigo Kitano |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-8-27 |
Journal Detail:
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Title: Obesity surgery Volume: - ISSN: 1708-0428 ISO Abbreviation: - Publication Date: 2011 Aug |
Date Detail:
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Created Date: 2011-8-29 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9106714 Medline TA: Obes Surg Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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Department of Surgery I, Oita University Faculty of Medicine, 1-1 Idaigaoka, Hasama-machi, Yufu, Oita, 879-5593, Japan, tmasuda@oita-u.ac.jp. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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