| A Comparative Study of the Effects of Three Root-end Filling Materials on Proliferation and Adherence of Human Periodontal Ligament Fibroblasts. | |
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MedLine Citation:
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PMID: 21787507 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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INTRODUCTION: The present in vitro study was conducted with the aim of evaluating and comparing the cytotoxic effects of three root-end filling materials, ProRoot mineral trioxide aggregate (ProRoot MTA; Dentsply Tulsa Dental, Memphis, TN), MTA Angelus (Angelus, Londrina, Brazil), and a modified zinc oxide-eugenol cement (Super-EBA; Bosworth Co, Skokie, IL) on human periodontal ligament (PDL) fibroblasts. METHODS: PDL cells were cultured in an mineral trioxide aggregate (MTA)- or a Super-EBA-conditioned medium to assess the viability as determined by the trypan blue exclusion assay. The proliferation of the cells was recorded, and the cellular morphology was observed by confocal microscopy. Moreover, PDL cell aggregates were cultured on the substrate surfaces to assess cell adhesion. RESULTS: ProRoot MTA was found to be the most biocompatible material, whereas Super-EBA was found to be the most cytotoxic material because it significantly inhibited the cell growth and adherence on its. In the presence of ProRoot MTA, the PDL cell proliferation was almost unaltered. MTA Angelus was found to be more cytotoxic than ProRoot MTA, offering, however, excellent scaffold properties for the adhesion of cell aggregates. CONCLUSIONS: Under the conditions of the present study, it seems that commercially available forms of MTA may behave in different ways regarding their proliferative effect on human PDL fibroblasts. ProRoot MTA appears to be the most biocompatible of the three tested materials when considering use for root-end endodontic microsurgery. |
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Authors:
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Athina Samara; Yvanna Sarri; Dimitrios Stravopodis; Giorgos N Tzanetakis; Evangelos G Kontakiotis; Ema Anastasiadou |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Journal of endodontics Volume: 37 ISSN: 1878-3554 ISO Abbreviation: J Endod Publication Date: 2011 Jun |
Date Detail:
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Created Date: 2011-07-26 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7511484 Medline TA: J Endod Country: United States |
Other Details:
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Languages: eng Pagination: 865-70 Citation Subset: D |
Copyright Information:
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Copyright © 2011 American Association of Endodontists. Published by Elsevier Inc. All rights reserved. |
Affiliation:
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Department of Endocrinology and Metabolism, Center of Clinical Research, Biomedical Research Foundation of the Academy of Athens, Athens, Greece. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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