| Comparative study of the effect of basal diet formulation, dietary fat and cholesterol levels on the development of aortic atherosclerotic lesions in B6.KOR-Apoeshl mice. | |
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MedLine Citation:
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PMID: 20299762 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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To optimize the adequate atherogenic diet composition for nutritional atherosclerosis studies utilizing B6.KOR-Apoe(shl) mice, we investigated the effect of dietary cholesterol, AIN formula, and dietary fats on the development of atherosclerosis. Cholesterol supplementation (0.15-2%) for 12 weeks resulted in a dose-dependent increase in the development of atherosclerosis. Furthermore, there were no significant differences in the degree of atherosclerosis between B6.KOR-Apoe(shl) mice fed a modified-AIN-76 diet and those fed a modified-AIN-93M diet containing corn oil or soybean oil for 10 and 12 weeks. The present experiment indicates that the adequate dietary level of cholesterol was 0.15%, and that further studies are necessary to determine the optimal level of various types of dietary oils for nutritional atherosclerosis experiments in B6.KOR-Apoe(shl) mice. |
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Authors:
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Takafumi Okabe; Takayoshi Toda; Natthanan Nukitrangsan; Masashi Inafuku; Hironori Iwasaki; Teruyoshi Yanagita; Hirosuke Oku |
Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Journal of oleo science Volume: 59 ISSN: 1347-3352 ISO Abbreviation: J Oleo Sci Publication Date: 2010 |
Date Detail:
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Created Date: 2010-03-19 Completed Date: 2010-06-22 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101175339 Medline TA: J Oleo Sci Country: Japan |
Other Details:
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Languages: eng Pagination: 161-7 Citation Subset: IM |
Affiliation:
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United Graduate School of Agricultural Sciences, Kagoshima University, Kagoshima, Japan. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Aortic Diseases / blood, etiology*, pathology Atherosclerosis / blood, etiology*, pathology Body Weight Cholesterol, Dietary / administration & dosage, adverse effects* Diet, Atherogenic* Dietary Fats / administration & dosage, adverse effects* Disease Models, Animal Genetic Predisposition to Disease Lipids / blood Male Mice Mice, Inbred C57BL Mice, Transgenic Time Factors |
| Chemical | |
Reg. No./Substance:
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0/Cholesterol, Dietary; 0/Dietary Fats; 0/Lipids |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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