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Comparative Pharmacokinetics Study after Oral Administration of Geniposide in Normal Rats and Adjuvant-induced Arthritis Rats by UPLC-MS/MS.
MedLine Citation:
PMID:  23953346     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
A simple and rapid ultra-performance liquid chromatography-electrospray ionization-tandem mass spectrometry (UPLC-ESI-MS/MS) method for quantitative analysis of geniposide (GE) in rat plasma was developed, validated and applied to determine the level of GE in rat plasma after oral administration of GE in adjuvant-induced arthritis (AA) and normal rats. The investigation showed that there were significant differences in the groups between the normal rat and AA rat in pharmacokinetics parameters, such as the area under the time versus drug concentration curve (AUC (0-∞) ) (3.77 ± 0.68 versus 2.27 ± 0.42, P < 0.05), the apparent volume of distribution (V) (140.41 ± 2.07 versus 136.51 ± 1.03, P < 0.05), the mean residence time (MRT) (3.98 ± 0.90 versus 3.80 ± 0.50, P < 0.05) and the clearance from the total body (CL) (16.10 ± 2.87 versus 26.44 ± 4.94, P < 0.05). The results indicated that AA could alter the pharmacokinetics of the drug and these experimental findings could be useful for the further study of the clinical applications of GE. This article is protected by copyright. All rights reserved.
Authors:
Hui Li; Hong Wu; Chen Shen; Jin-Yun Chen; Shun-Li Hu; Huan Wu
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2013-8-16
Journal Detail:
Title:  Basic & clinical pharmacology & toxicology     Volume:  -     ISSN:  1742-7843     ISO Abbreviation:  Basic Clin. Pharmacol. Toxicol.     Publication Date:  2013 Aug 
Date Detail:
Created Date:  2013-8-19     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101208422     Medline TA:  Basic Clin Pharmacol Toxicol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
This article is protected by copyright. All rights reserved.
Affiliation:
College of Pharmacy, Anhui University of Traditional Chinese Medicine, Key Laboratory of Modernized Chinese Medicine in Anhui Province, Hefei, Anhui, China.
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