| Comparative Investigation of IV Iohexol and Iopamidol: Effect on Renal Function in Low-Risk Outpatients Undergoing CT. | |
| | |
MedLine Citation:
|
PMID: 22268183 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
|
OBJECTIVE: The purpose of our study was to compare the effects of IV iohexol and iopamidol on renal function in outpatients undergoing CT. SUBJECTS AND METHODS: We performed a prospective, double-blind, randomized clinical trial of 389 adults with low risk for contrast-induced nephropathy, comparing IV iohexol with iopamidol (300 mg I/mL). Serum creatinine (SCr) concentration was measured at baseline and 2 and 3 days after contrast administration. A noninferiority analysis was planned to compare the mean maximum SCr change from baseline between subject groups. Contrast-induced nephropathy rates (three definitions) for both contrast agents were compared as a secondary end point. RESULTS: One hundred ninety and 199 subjects received iohexol and iopamidol, respectively. The mean change in SCr from baseline using the maximum day 2 or 3 measurement was 0.07 ± 0.12 mg/dL (95% CI, 0.05-0.09 mg/dL) for the iohexol group and 0.05 ± 0.12 mg/dL (95% CI, 0.03-0.07 mg/dL) for the iopamidol group. The difference between contrast agents with respect to the mean change in SCr from baseline was -0.02 ± 0.12 mg/dL (95% CI, -0.045 to 0.003 mg/dL; p = 0.08). Contrast-induced nephropathy rates were not statistically different using any definition. CONCLUSION: Although our results were unable to show absolute noninferiority of iohexol compared with iopamidol because of a very small difference in increase in mean SCr from baseline (using a noninferiority margin of 0.04 mg/dL), this difference is likely of minimal or no clinical importance in outpatients undergoing CT with low risk for contrast-induced nephropathy. |
| | |
Authors:
|
Jonathan R Dillman; Mahmoud Al-Hawary; James H Ellis; Richard H Cohan; Ravi Kaza; James D Myles; Shokoufeh Khalatbari; Isaac R Francis |
Related Documents
:
|
8513853 - Effects of diclofenac on isradipine pharmacokinetics and platelet aggregation in volunt... 11008973 - Phase i trial of the recombinant soluble complement receptor 1 in acute lung injury and... 17938803 - Pharmacokinetics of beriplex p/n prothrombin complex concentrate in healthy volunteers. |
Publication Detail:
|
Type: Journal Article |
Journal Detail:
|
Title: AJR. American journal of roentgenology Volume: 198 ISSN: 1546-3141 ISO Abbreviation: AJR Am J Roentgenol Publication Date: 2012 Feb |
Date Detail:
|
Created Date: 2012-01-23 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 7708173 Medline TA: AJR Am J Roentgenol Country: United States |
Other Details:
|
Languages: eng Pagination: 392-7 Citation Subset: AIM; IM |
Affiliation:
|
Department of Radiology, University of Michigan Health System, 1500 E Medical Center Dr, Ann Arbor, MI 48109-5252. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Perfusion MRI for monitoring the effect of sorafenib on experimental prostate carcinoma: a validatio...
Next Document: Designing a safer radiology department.