| Comparative immunological effect of anticoagulant and antioxidant therapy in the prevention of abortion in mice. | |
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MedLine Citation:
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PMID: 20645940 Owner: NLM Status: In-Process |
Abstract/OtherAbstract:
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PROBLEM: Considering the potential adverse effects of anticoagulation in abortion treatment, we investigate whether antioxidants might exert the same immunoprotection. Although the fertility properties of Vitamin E have been associated with its antioxidant capacity, its effect on cytokine balance during pregnancy is still unknown. METHOD OF STUDY: Pregnant females from CBA/J × DBA/2 abortion model were orally supplemented with Vitamin E or inoculated intraperitoneally with enoxaparin. Foeto-placental units were scored at 14.5 days of pregnancy, and abortion rate was calculated. Cytokine placental levels were determined by enzyme-linked immunosorbent assay. RESULTS: Vitamin E (15 mg/day) has been able to decrease abortion rate and to increase IL-6 placental levels, while both treatments increased vascular endothelial growth factor (VEGF) placental levels. CONCLUSION: Vitamin E and enoxaparin are able not only to prevent foetal wastage but also to balance IL-6 and VEGF placental levels, presenting a new potential therapeutic alternative for patients with recurrent abortion not associated with thrombophilias. |
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Authors:
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Gisela Junovich; Valeria Dubinsky; Teresa Gentile; Adriana Sarto; Sergio Pasqualini; Gabriela Gutiérrez |
Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: American journal of reproductive immunology (New York, N.Y. : 1989) Volume: 65 ISSN: 1600-0897 ISO Abbreviation: Am. J. Reprod. Immunol. Publication Date: 2011 Feb |
Date Detail:
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Created Date: 2011-01-07 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8912860 Medline TA: Am J Reprod Immunol Country: Denmark |
Other Details:
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Languages: eng Pagination: 104-9 Citation Subset: IM |
Copyright Information:
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© 2010 John Wiley & Sons A/S. |
Affiliation:
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IDEHU (CONICET)/Department of Immunology, School of Pharmacy and Biochemistry, University of Buenos Aires, Buenos Aires, Argentina Halitus Medical Institute, Buenos Aires, Argentina. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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