| Comparative Health-Care Cost Advantage of Ipratropium over Tiotropium in COPD Patients. | |
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MedLine Citation:
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PMID: 22433758 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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OBJECTIVE: To compare the total direct health-care costs of patients treated with tiotropium and ipratropium. METHODS: We conducted a cohort study of health-care costs in British Columbia, Canada, by comparing new patients on tiotropium with new patients on ipratropium. Direct health-care costs for study patients were measured in the first 2 years after initiating inhaled anticholinergic treatment. Differences in direct health-care costs between tiotropium and ipratropium patients were estimated by using quantile regression. We analyzed cost differences in the 10th percentile, median, and 90th percentile of patients by cost. High-dimensional propensity score analysis was used as a method of adjustment for potential confounding factors. RESULTS: The study population had 3,140 tiotropium patients and 26,182 ipratropium patients. Higher health system costs in patients who started on tiotropium instead of ipratropium were observed in patients in the median and 10th percentile. The magnitude of these increases was comparable to the price difference between the two drugs. Health system costs in the 90th percentile were not significantly different between tiotropium and ipratropium patients. CONCLUSIONS: The results of this study did not support the preferential use of tiotropium over ipratropium as a basis for savings in direct health-care costs. |
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Authors:
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Colin R Dormuth; Jesse Yamaguchi; Brett Wilmer; David Hosick; Til Stürmer; Greg Carney |
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Publication Detail:
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Type: Journal Article Date: 2012-02-09 |
Journal Detail:
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Title: Value in health : the journal of the International Society for Pharmacoeconomics and Outcomes Research Volume: 15 ISSN: 1524-4733 ISO Abbreviation: Value Health Publication Date: 2012 Mar |
Date Detail:
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Created Date: 2012-03-21 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 100883818 Medline TA: Value Health Country: United States |
Other Details:
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Languages: eng Pagination: 269-76 Citation Subset: IM |
Copyright Information:
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Copyright © 2012 International Society for Pharmacoeconomics and Outcomes Research (ISPOR). Published by Elsevier Inc. All rights reserved. |
Affiliation:
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Department of Anesthesiology, Pharmacology and Therapeutics, University of British Columbia, Vancouver, BC, Canada; Pharmacoepidemiology Group, University of British Columbia, Vancouver, BC, Canada. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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