| Comparative Efficacy of Aliskiren/Valsartan vs Valsartan in Nocturnal Dipper and Nondipper Hypertensive Patients: A Pooled Analysis. | |
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MedLine Citation:
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PMID: 22533656 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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J Clin Hypertens (Greenwich). 2012; 14:299-306. ©2012 Wiley Periodicals, Inc. This pooled analysis of ambulatory blood pressure (BP) monitoring data from two 8-week randomized controlled trials compared the antihypertensive efficacy and safety of combination aliskiren/valsartan vs valsartan alone in hypertensive patients (nocturnal dippers or nondippers). At study end, patients were taking aliskiren/valsartan 300/320 mg or valsartan 320 mg. In dippers (n=138) and nondippers (n=132), aliskiren/valsartan provided significantly (P<.05) greater reductions from baseline to week 8 than valsartan in 24-hour, daytime, and last-4-hour mean ambulatory systolic BP (maSBP). Treatment differences were more pronounced in nondippers. Nighttime maSBP reductions with aliskiren/valsartan were significantly greater vs valsartan in nondippers (-17.0 mm Hg vs -8.9 mm Hg; P<.05) but not dippers (-7.6 mm Hg vs -4.5 mm Hg; P=.16). In all time periods, combination therapy was generally associated with BP reductions that were greater in nondippers than dippers. Conversion from nondipper to dipper status was 32% vs 22% for aliskiren/valsartan vs valsartan (P=.48). Both treatments were similarly well tolerated. Although the addition of aliskiren to valsartan did not significantly alter dipper status, our data suggest an increased contribution of the renin-angiotensin-aldosterone system to the nondipper status of hypertensive patients. |
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Authors:
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Thomas D Giles; Thomas Alessi; Das Purkayastha; Dion Zappe |
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Publication Detail:
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Type: Journal Article Date: 2012-03-16 |
Journal Detail:
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Title: Journal of clinical hypertension (Greenwich, Conn.) Volume: 14 ISSN: 1751-7176 ISO Abbreviation: J Clin Hypertens (Greenwich) Publication Date: 2012 May |
Date Detail:
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Created Date: 2012-04-26 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 100888554 Medline TA: J Clin Hypertens (Greenwich) Country: United States |
Other Details:
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Languages: eng Pagination: 299-306 Citation Subset: IM |
Copyright Information:
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© 2012 Wiley Periodicals, Inc. |
Affiliation:
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From the Heart and Vascular Institute, Tulane University School of Medicine, New Orleans, LA;1 and the Novartis Pharmaceuticals Corporation, East Hanover, NJ 2. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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