Document Detail

Comparative effects of nesiritide and nitroglycerin on renal function, and incidence of renal injury by traditional and RIFLE criteria in acute heart failure.
MedLine Citation:
PMID:  21536855     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Acute renal insufficiency is associated with poorer outcomes in heart failure. Data regarding the renal effects of vasodilatory therapy in acute heart failure are inconclusive.
HYPOTHESIS: Nesiritide and nitroglycerin are associated with differing effects on the incidence of acute renal injury and glomerular filtration rate changes.
METHODS: A retrospective cohort study of patients hospitalized with acute congestive heart failure who received intravenous nesiritide or nitroglycerin for ≥6 hours. Acute kidney injury was assessed by risk, injury, failure, loss, and end stage (RIFLE) classification (creatinine/GFR criteria) and by traditional acute rise in creatinine of 0.3 mg/dL or 25%. Secondary endpoints included change in estimated glomerular filtration rate, serum creatinine, serum blood urea nitrogen, blood pressure, and urine output.
RESULTS: A total of one hundred and thirty-one patients (age 57 ± 12 years, 67% male, left ventricular ejection fraction 38 ± 35%, 30% ischemic) received nesiritide (N = 37) or nitroglycerin (N = 94). Diuretic regimen and doses were similar in both the groups. Mean duration of therapy was not different (nesiritide 38.6 ± 35.7 h vs nitroglycerin 30.7 ± 22.6 h, P = .13). No differences were detected in incidence of renal injury using either criteria (RIFLE: nesiritide 19% vs nitroglycerin 22%, P = .88; traditional: 22% vs 34%, P = .16); however, glomerular filtration rate declined (-1 ± 18 mL/min vs -9 ± 21 mL/min, P = .03) and blood urea nitrogen increased (-0.2 ± 9.9 mg/dL vs 4.2 ± 9.1 mg/dL, P = .02) to a greater degree with nitroglycerin. Nesiritide was associated with lower hourly blood pressures and a higher incidence of systolic blood pressure <80 mm Hg.
CONCLUSION: The incidence of renal injury was not different between nesiritide- and nitroglycerin-treated patients with acute heart failure; however, nitroglycerin was associated with a decline in glomerular filtration rate and increase in blood urea nitrogen despite higher baseline and on treatment blood pressures.
Tien M H Ng; Kimberly A Ackerbauer; Alifiya F Hyderi; Shenche Hshieh; Uri Elkayam
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Publication Detail:
Type:  Comparative Study; Journal Article     Date:  2011-05-02
Journal Detail:
Title:  Journal of cardiovascular pharmacology and therapeutics     Volume:  17     ISSN:  1940-4034     ISO Abbreviation:  J. Cardiovasc. Pharmacol. Ther.     Publication Date:  2012 Mar 
Date Detail:
Created Date:  2012-02-07     Completed Date:  2012-10-08     Revised Date:  2014-07-30    
Medline Journal Info:
Nlm Unique ID:  9602617     Medline TA:  J Cardiovasc Pharmacol Ther     Country:  United States    
Other Details:
Languages:  eng     Pagination:  79-85     Citation Subset:  IM    
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MeSH Terms
Acute Disease
Acute Kidney Injury / chemically induced*,  epidemiology,  physiopathology
Cohort Studies
Heart Failure / drug therapy*,  epidemiology,  physiopathology
Kidney Failure, Chronic / drug therapy*,  epidemiology,  physiopathology
Kidney Function Tests / methods,  trends
Middle Aged
Natriuretic Peptide, Brain / adverse effects*,  pharmacology
Nitroglycerin / adverse effects*,  pharmacology
Retrospective Studies
Risk Factors
Reg. No./Substance:
114471-18-0/Natriuretic Peptide, Brain; G59M7S0WS3/Nitroglycerin
Comment In:
J Cardiovasc Pharmacol Ther. 2012 Jun;17(2):229-30   [PMID:  22573645 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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