| Comparative effects of caffeine and albuterol on the bronchoconstrictor response to exercise in asthmatic athletes. | |
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MedLine Citation:
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PMID: 20148372 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The main aim of this study was to evaluate the comparative and additive effects of caffeine and albuterol (short-acting beta (2)-agonist) on the severity of EIB. Ten asthmatic subjects with EIB (exercise-induced bronchoconstriction) participated in a randomized, double-blind, double-dummy crossover study. One hour before an exercise challenge, each subject was given 0, 3, 6, or 9 mg/kg of caffeine or placebo mixed in a flavored sugar drink. Fifteen minutes before the exercise bout, an inhaler containing either albuterol (180 microg) or placebo was administered to each subject. Pulmonary function tests were conducted pre- and post-exercise. Caffeine at a dose of 6 and 9 mg/kg significantly reduced (p<0.05) the mean maximum % fall in post-exercise FEV (1) to -9.0+/-9.2% and -6.8+/-6.5% respectively compared to the double-placebo (-14.3+/-11.1%) and baseline (-18.4+/-7.2%). There was no significant difference (p>0.05) in the post-exercise % fall in FEV (1) between albuterol ( PLUS CAFFEINE PLACEBO) (-4.0+/-5.2%) and the 9 mg/kg dose of caffeine (-6.8+/-6.5%). Interestingly, there was no significant difference (p>0.05) in the post-exercise % fall in FEV (1) between albuterol ( PLUS CAFFEINE PLACEBO) (-4.0+/-5.2%) and albuterol with 3, 6 or 9 mg/kg of caffeine (-4.4+/-3.8, -6.8+/-5.6, -4.4+/-6.0% respectively). Similar changes were observed for the post-exercise % fall in FVC, FEF (25-75%) and PEF. These data indicate that moderate (6 mg/kg) to high doses (9 mg/kg) of caffeine provide a significant protective effect against EIB. It is feasible that the negative effects of daily use of short-acting beta (2)-agonists by asthmatic athletes could be reduced simply by increasing caffeine consumption prior to exercise. |
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Authors:
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T A VanHaitsma; T Mickleborough; J M Stager; D M Koceja; M R Lindley; R Chapman |
Publication Detail:
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Type: Journal Article; Randomized Controlled Trial Date: 2010-02-10 |
Journal Detail:
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Title: International journal of sports medicine Volume: 31 ISSN: 1439-3964 ISO Abbreviation: Int J Sports Med Publication Date: 2010 Apr |
Date Detail:
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Created Date: 2010-04-26 Completed Date: 2010-08-24 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8008349 Medline TA: Int J Sports Med Country: Germany |
Other Details:
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Languages: eng Pagination: 231-6 Citation Subset: IM |
Copyright Information:
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Copyright Georg Thieme Verlag KG Stuttgart . New York. |
Affiliation:
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University of Utah, Exercise and Sports Science, Salt Lake City, United States. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Albuterol
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pharmacology,
therapeutic use* Analysis of Variance Asthma / drug therapy, etiology, physiopathology Bronchoconstriction / drug effects* Bronchodilator Agents / pharmacology, therapeutic use* Caffeine / pharmacology, therapeutic use* Central Nervous System Stimulants / pharmacology, therapeutic use* Cross-Over Studies Double-Blind Method Drug Synergism Exercise / physiology* Exercise Test Female Humans Male Questionnaires Respiratory Function Tests Severity of Illness Index Sports / physiology Young Adult |
| Chemical | |
Reg. No./Substance:
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0/Bronchodilator Agents; 0/Central Nervous System Stimulants; 18559-94-9/Albuterol; 58-08-2/Caffeine |
| Comments/Corrections | |
Erratum In:
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Int J Sports Med. 2010 Jun;31(6):439 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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