| Comparative Drug Dose and Drug Combinations in Patients that present to Hospital due to Self-Poisoning. | |
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MedLine Citation:
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PMID: 22510218 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Self-poisoning is a common reason for acute presentation to hospital. Commonly involved drugs have been reported, but few data exist concerning the different combinations of agents or comparative doses ingested. The present study sought to better characterise the typical patterns of drug overdose that may present via the emergency department. Consecutive adults ≥16 years of age that presented to York Hospital due to self-poisoning were studied for 2010-2011 inclusive. The primary outcome measure was reported dose, expressed as a multiple of the defined daily dose (DDD) to allow comparison between different agents. There were 1024 patients, including 622 women (60.7%), and median age was 32 years (range 16 to 92 years). Overdose in men was associated with a higher overall quantity of drugs: arithmetic mean 20 DDD multiples (95% CI 15-26) versus 13 (11-15), P=0.001. Overdose involved a single agent only in 538 patients (52.5%); common drug combinations are described. The mean paracetamol dose was 4.0 (95% CI 3.7-4.3) DDD multiples; the doses of antidepressants (19.4, 17.0-21.7, P<0.0001) and benzodiazepines (18.0, 12.8-23.2, P<0.0001) were comparatively higher. The types of agents involved in self-poisoning and common combinations of agents are characterised. Psychotropic medications were ingested in comparatively larger quantities than analgesic agents and had worse clinical outcome. Further work is required to understand the factors that determine the quantity of drug ingested in patients at risk of drug overdose so as to minimise the risk of significant toxicity. |
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Authors:
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Thomas M Armstrong; Matthew S Davies; Gary Kitching; W Stephen Waring |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2012-4-17 |
Journal Detail:
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Title: Basic & clinical pharmacology & toxicology Volume: - ISSN: 1742-7843 ISO Abbreviation: - Publication Date: 2012 Apr |
Date Detail:
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Created Date: 2012-4-18 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101208422 Medline TA: Basic Clin Pharmacol Toxicol Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
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© 2012 The Authors Basic & Clinical Pharmacology & Toxicology © 2012 Nordic Pharmacological Society. |
Affiliation:
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Acute Medical Unit, York Hospital, York, United Kingdom. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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