Document Detail

Comparative Cell Behavior on Carbon Coated TiO(2) Nanotube Surfaces for Osteoblasts vs. Osteo-progenitor Cells.
MedLine Citation:
PMID:  21382531     Owner:  NLM     Status:  Publisher    
Surface engineering approaches that alter the topological chemistry of a substrate could be used as an effective tool for directing cell interactions and their subsequent function. It is well known that the physical environment of nanotopography has positive effects on cell behavior, yet direct comparisons of nanotopographic surface chemistry has not been fully explored. Here within we compare TiO(2) nanotubes vs. carbon coated TiO(2) nanotubes for probing osteogenic cell behaviors, including osteoblast (bone cells) and mesenchymal stem cell (MSC) (osteo-progenitor cells) interaction with the different surface chemistries (TiO(2) vs. carbon). The roles played by the material surface chemistry of the nanotubes did not have an effect on the adhesion, growth or morphology, but had major influence on the alkaline phosphatase (ALP) activity of osteoblast cells, where the original TiO(2) chemistry had superior ALP levels. In addition, the chemistry effect caused different levels of the osteogenic differentiation in MSCs; however, it was the carbon coated TiO(2) nanotubes having the greater advantage with higher levels of osteo-differentiation. It was observed in this study that (a) chemistry plays a role in cell functionality, such as ALP activity and osteogenic protein gene expression (PCR), and (b) different cell types may have different chemical preferences for optimal function. The ability to optimize cell behavior, using surface chemistry factors, has a profound effect on both orthopedic and tissue engineering in general. This study aims to highlight the importance of the chemistry of the material carrier in osteogenic tissue engineering schemes.
Karla S Brammer; Chulmin Choi; Christine J Frandsen; Seunghan Oh; Gary Johnston; Sungho Jin
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-3-4
Journal Detail:
Title:  Acta biomaterialia     Volume:  -     ISSN:  1878-7568     ISO Abbreviation:  -     Publication Date:  2011 Mar 
Date Detail:
Created Date:  2011-3-8     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101233144     Medline TA:  Acta Biomater     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2011. Published by Elsevier Ltd.
Materials Science & Engineering, University of California, San Diego, La Jolla, California, USA.
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