| Comparative Analysis of Ferumoxytol and Gadoteridol Enhancement Using T1- and T2-Weighted MRI in Neuroimaging. | |
| | |
MedLine Citation:
|
PMID: 21940589 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
|
OBJECTIVE: Ferumoxytol, an ultrasmall superparamagnetic iron oxide particle, has been suggested as a potential alternative MRI contrast agent in patients with renal failure. We compared ferumoxytol to gadoteridol enhancement on T1- and T2-weighted MRI in CNS disorders to explore its diagnostic utility. SUBJECTS AND METHODS: Data were collected from three protocols in 70 adults who underwent alternate-day gadoteridol- and ferumoxytol-enhanced MRI using identical parameters. Two neuroradiologists measured lesion-enhancing size and intensity on contrast-enhanced T1-weighted images in consensus. T2-weighted images were evaluated for the presence of contrast-enhanced hypointensity. Mixed model repeated measures analysis of variance determined differences between T1-weighted enhancement size and intensity for individual protocols and group. RESULTS: After exclusions, 49 MRI studies in 29 men and 20 women (mean age, 51 years) were assessed. T1-weighted estimated enhancing sizes were different between agents (p = 0.0456) as a group; however, no differences were observed with untreated gliomas (n = 17) in two protocols (p = 1.0 and p = 0.99, respectively). Differences in T1-weighted enhancement intensity between agents were significant for the group overall (p = 0.0006); however, three-way interactions were not significant (p = 0.1233). T2-weighted images were assessed for contrast-enhanced hypointensity, observed in 26 of 49 (53%) ferumoxytol and zero of 49 (0%) gadoteridol scans. CONCLUSION: Ferumoxytol may be a useful MRI contrast agent in patients who are unable to receive gadolinium-based contrast agents. Greater experience with a wider variety of disorders is necessary to understand differences in enhancement with ferumoxytol compared with gadolinium-based contrast agents, given their different mechanisms of action. |
| | |
Authors:
|
Bronwyn E Hamilton; Gary M Nesbit; Edit Dosa; Seymur Gahramanov; Bill Rooney; Eric G Nesbit; Joshua Raines; Edward A Neuwelt |
Related Documents
:
|
19097099 - Imaging age-related cognitive decline: a comparison of diffusion tensor and magnetizati... 16518169 - Diffusion tensor magnetic resonance imaging. 16431139 - Collateral nerve fibers in human spinal cord: visualization with magnetic resonance dif... 21872129 - Dynamic t1 functional mri examinations with use of blood pool contrast agent - an appro... 18003529 - Application of lattice boltzmann method to image segmentation. 10519699 - Magnetic resonance imaging procedures to study the concurrent anatomic development of v... 21423079 - Cervical spine chondroma arising from c5 right hemilamina: a rare cause of spinal cord ... 20602779 - How reliable is mri in diagnosing cartilaginous lesions in patients with first and recu... 19484399 - Degenerative changes were common in brain magnetic resonance imaging in patients with n... |
Publication Detail:
|
Type: JOURNAL ARTICLE |
Journal Detail:
|
Title: AJR. American journal of roentgenology Volume: 197 ISSN: 1546-3141 ISO Abbreviation: - Publication Date: 2011 Oct |
Date Detail:
|
Created Date: 2011-9-23 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 7708173 Medline TA: AJR Am J Roentgenol Country: - |
Other Details:
|
Languages: ENG Pagination: 981-988 Citation Subset: - |
Affiliation:
|
Department of Radiology, Oregon Health and Science University, 3181 SW Sam Jackson Park Rd, Mail Code CR 135, Portland, OR 97239. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Use of 18F-FDG PET/CT as a Predictive Biomarker of Outcome in Patients With Head-and-Neck Non-Squamo...
Next Document: Next Generation Radiologic-Pathologic Correlation in Oncology: Rad-Path 2.0.