Document Detail


Comparable outcomes between Unrelated and Related donors after Reduced Intensity Conditioning Allogeneic hematopoietic Stem Cell Transplantation in patients with high risk Multiple Myeloma.
MedLine Citation:
PMID:  22385049     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
The purpose of this study was to assess the results of allogeneic stem cell transplantation (Allo-SCT) after reduced-intensity conditioning (RIC) from matched related donors (MRD) and unrelated donor (URD) in 40 patients with high-risk multiple myeloma (MM) in a single centre. Seventeen (43%) (Group 1) and 23 patients (57%) (Group 2) had URD and MRD respectively. Thirty nine patients (98%) received one or more autologous transplantation. The median follow-up was 22 months (1-49). None of our patient experienced a graft rejection. The cumulative incidence of grade II-IV acute GVHD was higher (47%) for the URD vs. (17%) for the MRD (p= 0.092). The cumulative incidence of chronic GVHD was no different between the two groups (24% vs. 30% respectively). At two-year the TRM probabilities was lower in the unrelated group 12% vs. 22% in the related group (p =0,4). Also at 2 years, for patients receiving unrelated transplantation overall and progression-free survivals, 59% and 42% respectively compared to patients with related donor transplantation, 66% and 44% (p= 0.241). In conclusion, these results suggest that URD in MM is feasible. The small number of patients with URD, emphasize the need to delineate indications and perform prospective protocols © 2012 John Wiley & Sons A/S.
Authors:
Jean El-Cheikh; Roberto Crocchiolo; Jean-Marie Boher; Sabine Furst; Anne-Marie Stoppa; Patrick Ladaique; Catherine Faucher; Boris Calmels; Luca Castagna; Claude Lemarie; Jean-Marc Schiano De Colella; Diane Coso; Reda Bouabdallah; Christian Chabannon; Didier Blaise
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-3-3
Journal Detail:
Title:  European journal of haematology     Volume:  -     ISSN:  1600-0609     ISO Abbreviation:  -     Publication Date:  2012 Mar 
Date Detail:
Created Date:  2012-3-5     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8703985     Medline TA:  Eur J Haematol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
© 2012 John Wiley & Sons A/S.
Affiliation:
Unité de Transplantation et de Thérapie Cellulaire (U2T), Institut Paoli-Calmettes, Marseille, France. Département d'Onco-Hématologie, Institut Paoli-Calmettes, Marseille, France. Département de bio statistique, Institut Paoli-Calmettes, Marseille, France Centre de Thérapie Cellulaire, Institut Paoli-Calmettes, Marseille, France.
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