| Comparable outcomes between Unrelated and Related donors after Reduced Intensity Conditioning Allogeneic hematopoietic Stem Cell Transplantation in patients with high risk Multiple Myeloma. | |
| | |
MedLine Citation:
|
PMID: 22385049 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
|
The purpose of this study was to assess the results of allogeneic stem cell transplantation (Allo-SCT) after reduced-intensity conditioning (RIC) from matched related donors (MRD) and unrelated donor (URD) in 40 patients with high-risk multiple myeloma (MM) in a single centre. Seventeen (43%) (Group 1) and 23 patients (57%) (Group 2) had URD and MRD respectively. Thirty nine patients (98%) received one or more autologous transplantation. The median follow-up was 22 months (1-49). None of our patient experienced a graft rejection. The cumulative incidence of grade II-IV acute GVHD was higher (47%) for the URD vs. (17%) for the MRD (p= 0.092). The cumulative incidence of chronic GVHD was no different between the two groups (24% vs. 30% respectively). At two-year the TRM probabilities was lower in the unrelated group 12% vs. 22% in the related group (p =0,4). Also at 2 years, for patients receiving unrelated transplantation overall and progression-free survivals, 59% and 42% respectively compared to patients with related donor transplantation, 66% and 44% (p= 0.241). In conclusion, these results suggest that URD in MM is feasible. The small number of patients with URD, emphasize the need to delineate indications and perform prospective protocols © 2012 John Wiley & Sons A/S. |
| | |
Authors:
|
Jean El-Cheikh; Roberto Crocchiolo; Jean-Marie Boher; Sabine Furst; Anne-Marie Stoppa; Patrick Ladaique; Catherine Faucher; Boris Calmels; Luca Castagna; Claude Lemarie; Jean-Marc Schiano De Colella; Diane Coso; Reda Bouabdallah; Christian Chabannon; Didier Blaise |
Related Documents
:
|
2702399 - Radionuclide imaging of ureteric peristalsis. 3880929 - Simple ureteroceles--ultrasonographic recognition and diagnosis of complications. 9516009 - Fetal renal biopsies in obstructive uropathy: feasibility and clinical correlations--pr... 847739 - A constant electrical activity of the renal pelvis correlated to ureteral peristalsis. 801099 - Ureteric necrosis after kidney transplantation. 12557039 - Prenatal therapy for obstructive uropathy. 15364559 - Current endovascular management of atherosclerotic renal artery stenosis. 12444209 - Endothelial dilatory function predicts individual susceptibility to renal damage in the... 21799149 - Graft loss due to recurrent lupus nephritis in living-related kidney donation. |
Publication Detail:
|
Type: JOURNAL ARTICLE Date: 2012-3-3 |
Journal Detail:
|
Title: European journal of haematology Volume: - ISSN: 1600-0609 ISO Abbreviation: - Publication Date: 2012 Mar |
Date Detail:
|
Created Date: 2012-3-5 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 8703985 Medline TA: Eur J Haematol Country: - |
Other Details:
|
Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
|
© 2012 John Wiley & Sons A/S. |
Affiliation:
|
Unité de Transplantation et de Thérapie Cellulaire (U2T), Institut Paoli-Calmettes, Marseille, France. Département d'Onco-Hématologie, Institut Paoli-Calmettes, Marseille, France. Département de bio statistique, Institut Paoli-Calmettes, Marseille, France Centre de Thérapie Cellulaire, Institut Paoli-Calmettes, Marseille, France. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Turmeric (Curcuma longa L.) volatile oil inhibits key enzymes linked to type 2 diabetes.
Next Document: The relationship between compulsive exercise and emotion regulation in adolescents.