Document Detail

Comparable sensitivity of postmenopausal and young women to the effects of intranasal insulin on food intake and working memory.
MedLine Citation:
PMID:  20719831     Owner:  NLM     Status:  MEDLINE    
CONTEXT: We have previously shown that enhancing brain insulin signaling by intranasal administration of a single dose of the hormone acutely reduces food intake in young men but not women, whereas its improving effects on spatial and working memory are restricted to young women.
OBJECTIVE: Against the background of animal studies suggesting that low estrogen concentrations are a prerequisite for the anorexigenic impact of central nervous insulin, we extended our foregoing study by assessing intranasal insulin effects in postmenopausal women with comparatively low estrogen concentrations, expecting them to be more sensitive than young women to the anorexigenic effects of the hormone.
DESIGN, SETTING, PARTICIPANTS, AND INTERVENTION: In a within-subject, double-blind comparison performed at the University of Lübeck, 14 healthy postmenopausal women (body mass index, 23.71±0.6 kg/m2; age, 57.61±1.14 yr) were intranasally administered 160 IU regular human insulin or vehicle.
MAIN OUTCOME MEASURES: Subjects performed a working memory task (digit span) and a hippocampus-dependent visuospatial memory task. Subsequently, free-choice food intake from an ad libitum breakfast buffet was measured.
RESULTS: Contrary to expectations, results in postmenopausal women mirrored those found in young women (22.44±0.63 yr), i.e. insulin administration did not affect food intake (P>0.46), but did enhance performance in the prefrontal cortex-dependent working memory task (P<0.05).
CONCLUSIONS: Low estrogen levels as present in postmenopausal women do not modulate the effects of intranasal insulin in females, suggesting that in humans as opposed to rats, estrogen signaling does not critically alter central nervous system sensitivity to the effects of insulin on energy homeostasis and cognition.
Rosemarie Krug; Christian Benedict; Jan Born; Manfred Hallschmid
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2010-08-18
Journal Detail:
Title:  The Journal of clinical endocrinology and metabolism     Volume:  95     ISSN:  1945-7197     ISO Abbreviation:  J. Clin. Endocrinol. Metab.     Publication Date:  2010 Dec 
Date Detail:
Created Date:  2010-12-06     Completed Date:  2011-01-14     Revised Date:  2013-11-06    
Medline Journal Info:
Nlm Unique ID:  0375362     Medline TA:  J Clin Endocrinol Metab     Country:  United States    
Other Details:
Languages:  eng     Pagination:  E468-72     Citation Subset:  AIM; IM    
Department of Neuroendocrinology, University of Lübeck, Ratzeburger Allee 160, Hs. 50.1, 23538 Lübeck, Germany.
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MeSH Terms
Administration, Intranasal
Blood Glucose / drug effects,  metabolism
C-Peptide / blood
Double-Blind Method
Energy Intake
Ghrelin / blood
Hippocampus / drug effects,  physiology*
Hypoglycemic Agents / pharmacology
Insulin / administration & dosage*,  blood,  pharmacology*
Leptin / blood
Memory / drug effects*
Middle Aged
Prefrontal Cortex / drug effects,  physiology
Reference Values
Sex Characteristics
Space Perception / drug effects
Vision, Ocular / drug effects,  physiology
Reg. No./Substance:
0/Blood Glucose; 0/C-Peptide; 0/Ghrelin; 0/Hypoglycemic Agents; 0/Insulin; 0/Leptin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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