Document Detail


Compact zwitterion-coated iron oxide nanoparticles for in vitro and in vivo imaging.
MedLine Citation:
PMID:  23042209     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
We have recently developed compact and water-soluble zwitterionic dopamine sulfonate (ZDS) ligand coated superparamagnetic iron oxide nanoparticles (SPIONs) for use in various biomedical applications. The defining characteristics of ZDS-coated SPIONs are small hydrodynamic diameters, low non-specific interactions with fetal bovine serum, the opportunity for specific labeling, and stability with respect to time, pH, and salinity. We report here on the magnetic characterization of ZDS-coated SPIONs and their in vitro and in vivo performance relative to non-specific interactions with HeLa cells and in mice, respectively. ZDS-coated SPIONs retained the superparamagnetism and saturation magnetization (M(s)) of as-synthesized hydrophobic SPIONs, with M(s) = 74 emu g(-1) [Fe]. Moreover, ZDS-coated SPIONs showed only small non-specific uptake into HeLa cancer cells in vitro and low non-specific binding to serum proteins in vivo in mice.
Authors:
He Wei; Oliver T Bruns; Ou Chen; Moungi G Bawendi
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.    
Journal Detail:
Title:  Integrative biology : quantitative biosciences from nano to macro     Volume:  5     ISSN:  1757-9708     ISO Abbreviation:  Integr Biol (Camb)     Publication Date:  2013 Jan 
Date Detail:
Created Date:  2012-12-17     Completed Date:  2013-06-24     Revised Date:  2014-01-09    
Medline Journal Info:
Nlm Unique ID:  101478378     Medline TA:  Integr Biol (Camb)     Country:  England    
Other Details:
Languages:  eng     Pagination:  108-14     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Cattle
Coated Materials, Biocompatible / chemical synthesis,  diagnostic use
Contrast Media / chemical synthesis,  pharmacokinetics
Dextrans / chemistry,  diagnostic use*
Dopamine / chemistry,  diagnostic use*,  pharmacokinetics*
Drug Stability
HeLa Cells
Humans
Ions
Magnetic Resonance Imaging / methods*
Magnetite Nanoparticles / chemistry,  diagnostic use*
Male
Metabolic Clearance Rate
Mice
Molecular Conformation
Molecular Imaging / methods*
Tissue Distribution
Grant Support
ID/Acronym/Agency:
1U54-CA119349/CA/NCI NIH HHS; R01 CA126642/CA/NCI NIH HHS; R01-CA126642/CA/NCI NIH HHS
Chemical
Reg. No./Substance:
0/Coated Materials, Biocompatible; 0/Contrast Media; 0/Ions; 0/Magnetite Nanoparticles; 0/ferumoxtran-10; K3R6ZDH4DU/Dextrans; VTD58H1Z2X/Dopamine
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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