| A compact mock circulation loop for the in vitro testing of cardiovascular devices. | |
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MedLine Citation:
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PMID: 20883450 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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In vitro cardiovascular device performance evaluation in a mock circulation loop (MCL) is a necessary step prior to in vivo testing. A MCL that accurately represents the physiology of the cardiovascular system accelerates the assessment of the device's ability to treat pathological conditions. To serve this purpose, a compact MCL measuring 600 × 600 × 600 mm (L × W × H) was constructed in conjunction with a computer mathematical simulation. This approach allowed the effective selection of physical loop characteristics, such as pneumatic drive parameters, to create pressure and flow, and pipe dimensions to replicate the resistance, compliance, and fluid inertia of the native cardiovascular system. The resulting five-element MCL reproduced the physiological hemodynamics of a healthy and failing heart by altering ventricle contractility, vascular resistance/compliance, heart rate, and vascular volume. The effects of interpatient anatomical variability, such as septal defects and valvular disease, were also assessed. Cardiovascular hemodynamic pressures (arterial, venous, atrial, ventricular), flows (systemic, bronchial, pulmonary), and volumes (ventricular, stroke) were analyzed in real time. The objective of this study is to describe the developmental stages of the compact MCL and demonstrate its value as a research tool for the accelerated development of cardiovascular devices. |
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Authors:
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Daniel L Timms; Shaun D Gregory; Nicholas A Greatrex; Mark J Pearcy; John F Fraser; Ulrich Steinseifer |
Publication Detail:
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Type: Journal Article Date: 2010-09-30 |
Journal Detail:
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Title: Artificial organs Volume: 35 ISSN: 1525-1594 ISO Abbreviation: Artif Organs Publication Date: 2011 Apr |
Date Detail:
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Created Date: 2011-04-19 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7802778 Medline TA: Artif Organs Country: United States |
Other Details:
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Languages: eng Pagination: 384-91 Citation Subset: IM |
Copyright Information:
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© 2010, Copyright the Author. Artificial Organs © 2010, International Center for Artificial Organs and Transplantation and Wiley Periodicals, Inc. |
Affiliation:
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The Prince Charles Hospital, Critical Care Research Group, Chermside, Brisbane, Queensland, Australia Department of Applied Medical Engineering, Helmholtz Institute, RWTH Aachen University, Aachen, Germany School of Engineering Systems, Queensland University of Technology, Brisbane, Queensland, Australia. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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