Document Detail

Comorbidity of insomnia and depression.
MedLine Citation:
PMID:  19939713     Owner:  NLM     Status:  MEDLINE    
During the last decade, several studies have shown that insomnia, rather than a symptom of depression, could be a medical condition on its own, showing high comorbidity with depression. Epidemiological research indicates that insomnia could lead to depression and/or that common causalities underlie the two disorders. Neurobiological and sleep EEG studies suggest that a heightened level of arousal may play a common role in both conditions and that signs of REM sleep disinhibition may appear in individuals prone to depression. The effects of antidepressant drugs on non-REM and REM sleep are discussed in relation to their use in insomnia comorbid with depression. Empirical treatment approaches are behavioral management of sleep combined with prescription of a sedative antidepressant alone, co-prescription of two antidepressants, or of an antidepressant with a hypnotic drug.
Luc Staner
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Publication Detail:
Type:  Journal Article; Review     Date:  2009-11-25
Journal Detail:
Title:  Sleep medicine reviews     Volume:  14     ISSN:  1532-2955     ISO Abbreviation:  Sleep Med Rev     Publication Date:  2010 Feb 
Date Detail:
Created Date:  2010-02-03     Completed Date:  2010-04-26     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9804678     Medline TA:  Sleep Med Rev     Country:  England    
Other Details:
Languages:  eng     Pagination:  35-46     Citation Subset:  IM    
Copyright Information:
Copyright 2009 Elsevier Ltd. All rights reserved.
Sleep Laboratory, Forenap, Centre Hospitalier de Rouffach, 27 rue du 4?me R.S.M. F-68250 Rouffach, France.
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MeSH Terms
Behavior Therapy
Combined Modality Therapy
Depressive Disorder / epidemiology*
Hypnotics and Sedatives / therapeutic use
Sleep Initiation and Maintenance Disorders / drug therapy,  epidemiology*,  therapy*
Sleep, REM / physiology
Reg. No./Substance:
0/Hypnotics and Sedatives

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