| Comorbidity of epilepsy and headache in patients with Sturge-Weber syndrome. | |
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MedLine Citation:
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PMID: 16225815 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Sturge-Weber syndrome is associated with leptomeningeal angioma, trigeminal port-wine stain, epilepsy, and glaucoma. Clinically, many patients with Sturge-Weber syndrome are observed to have both seizures and headaches, but this has never been described in the literature. A questionnaire was mailed to 190 patients with reported comorbid epilepsy and headache as identified by the Sturge-Weber Foundation. Sixty-eight surveys were returned anonymously; 55 reported both seizures and headaches. The median age at headache onset was 8 years, with a median of three headaches per month. Fifty-eight percent felt that headaches were an equal or greater problem. Ibuprofen and acetaminophen were the most frequently tried abortive medications; 22% had tried sumatriptan. Only 22% reported a neurologist suggesting the use of an anticonvulsant as a preventive agent. Subjects with a family history of headaches had an earlier age at headache onset (7.5 vs 11 years; P = .02), and those with a family history of seizures were more likely to report behavior problems (69% vs 33%; P = .02). Subjects reporting learning problems or hemiparesis had an earlier age at seizure onset. Migraine-like headaches can be as significant a problem as epilepsy for patients with Sturge-Weber syndrome. Despite this, triptans and prophylactic medications (including anticonvulsants) were used in less than half of the patients. Correlations of family history with both age at symptom onset and behavior problems suggest that genetic substrate could be one factor determining the variable neurologic manifestations seen in Sturge-Weber syndrome. |
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Authors:
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Eric H Kossoff; Laura A Hatfield; Karen L Ball; Anne M Comi |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Journal of child neurology Volume: 20 ISSN: 0883-0738 ISO Abbreviation: J. Child Neurol. Publication Date: 2005 Aug |
Date Detail:
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Created Date: 2005-10-17 Completed Date: 2006-02-24 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8606714 Medline TA: J Child Neurol Country: Canada |
Other Details:
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Languages: eng Pagination: 678-82 Citation Subset: IM |
Affiliation:
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Department of Neurology, The Johns Hopkins Medical Institutions, Baltimore, MD, USA. ekossoff@jhmi.edu |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Age of Onset Anticonvulsants / therapeutic use Child Child Behavior Disorders / etiology Child, Preschool Comorbidity Cross-Sectional Studies Epilepsy / drug therapy, etiology*, genetics Female Genetic Predisposition to Disease Headache / drug therapy, etiology* Humans Male Pedigree Severity of Illness Index Sturge-Weber Syndrome / complications* |
| Chemical | |
Reg. No./Substance:
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0/Anticonvulsants |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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