Document Detail


Comorbidities in primary aldosteronism.
MedLine Citation:
PMID:  20049673     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Patients presenting with primary aldosteronism experience more cardiovascular events than patients with essential hypertension independent of blood pressure. Therefore, the presence of primary aldosteronism should be detected, not only to determine the cause of hypertension, but also to prevent such complications. This review focuses on human data regarding increased end-organ damage and comorbidities in primary aldosteronism. Special emphasis is put on the effects of aldosterone excess on blood vessels, the heart, the kidney, and the brain. The data reviewed in our article demonstrate that primary aldosteronism is associated with a prevalence of cerebro-, cardiovascular and renal complications that are out of proportion to the blood pressure and benefits substantially from treatment in the long term. In this view, adrenalectomy and aldosterone antagonist treatment seem to be of considerable therapeutic value to control and limit the progression of comorbidities in primary aldosteronism.
Authors:
M Quinkler; E Born-Frontsberg; V G Fourkiotis
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Publication Detail:
Type:  Journal Article; Review     Date:  2010-01-04
Journal Detail:
Title:  Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et métabolisme     Volume:  42     ISSN:  1439-4286     ISO Abbreviation:  Horm. Metab. Res.     Publication Date:  2010 Jun 
Date Detail:
Created Date:  2010-05-26     Completed Date:  2010-09-08     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0177722     Medline TA:  Horm Metab Res     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  429-34     Citation Subset:  IM    
Copyright Information:
Georg Thieme Verlag KG Stuttgart-New York.
Affiliation:
Clinical Endocrinology, Charité Campus Mitte, Charité University Medicine Berlin, Berlin, Germany. marcus.quinkler@charite.de
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MeSH Terms
Descriptor/Qualifier:
Blood Vessels / physiopathology
Cardiovascular Diseases / complications,  epidemiology
Cerebrovascular Disorders / complications,  epidemiology
Comorbidity
Heart / physiopathology
Humans
Hyperaldosteronism / complications,  epidemiology*,  physiopathology
Kidney Diseases / complications,  epidemiology
Mental Disorders / complications,  epidemiology
Metabolic Syndrome X / complications,  epidemiology
Sleep Apnea Syndromes / complications,  epidemiology

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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