| Comorbidities in primary aldosteronism. | |
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MedLine Citation:
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PMID: 20049673 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Patients presenting with primary aldosteronism experience more cardiovascular events than patients with essential hypertension independent of blood pressure. Therefore, the presence of primary aldosteronism should be detected, not only to determine the cause of hypertension, but also to prevent such complications. This review focuses on human data regarding increased end-organ damage and comorbidities in primary aldosteronism. Special emphasis is put on the effects of aldosterone excess on blood vessels, the heart, the kidney, and the brain. The data reviewed in our article demonstrate that primary aldosteronism is associated with a prevalence of cerebro-, cardiovascular and renal complications that are out of proportion to the blood pressure and benefits substantially from treatment in the long term. In this view, adrenalectomy and aldosterone antagonist treatment seem to be of considerable therapeutic value to control and limit the progression of comorbidities in primary aldosteronism. |
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Authors:
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M Quinkler; E Born-Frontsberg; V G Fourkiotis |
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Publication Detail:
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Type: Journal Article; Review Date: 2010-01-04 |
Journal Detail:
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Title: Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et métabolisme Volume: 42 ISSN: 1439-4286 ISO Abbreviation: Horm. Metab. Res. Publication Date: 2010 Jun |
Date Detail:
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Created Date: 2010-05-26 Completed Date: 2010-09-08 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0177722 Medline TA: Horm Metab Res Country: Germany |
Other Details:
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Languages: eng Pagination: 429-34 Citation Subset: IM |
Copyright Information:
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Georg Thieme Verlag KG Stuttgart-New York. |
Affiliation:
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Clinical Endocrinology, Charité Campus Mitte, Charité University Medicine Berlin, Berlin, Germany. marcus.quinkler@charite.de |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Blood Vessels
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physiopathology Cardiovascular Diseases / complications, epidemiology Cerebrovascular Disorders / complications, epidemiology Comorbidity Heart / physiopathology Humans Hyperaldosteronism / complications, epidemiology*, physiopathology Kidney Diseases / complications, epidemiology Mental Disorders / complications, epidemiology Metabolic Syndrome X / complications, epidemiology Sleep Apnea Syndromes / complications, epidemiology |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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