| Comorbidities in Perthes' disease: A case control study using the General Practice Research Database. | |
| | |
MedLine Citation:
|
PMID: 23188912 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
|
Perthes' disease is an osteonecrosis of the juvenile hip, the aetiology of which is unknown. A number of comorbid associations have been suggested that may offer insights into aetiology, yet the strength and validity of these are unclear. This study explored such associations through a case control study using the United Kingdom General Practice Research database. Associations investigated were those previously suggested within the literature. A total of 619 cases of Perthes' disease were included, as were 2544 controls. The risk of Perthes' disease was significantly increased with the presence of congenital anomalies of the genitourinary and inguinal region, such as hypospadias (odds ratio (OR) 4.04 (95% confidence interval (CI) 1.41 to 11.58)), undescended testis (OR 1.83 (95% CI 1.12 to 3.00)) and inguinal herniae (OR 1.79 (95% CI 1.02 to 3.16)). Attention deficit hyperactivity disorder was not associated with Perthes' disease (OR 1.01 (95% CI 0.48 to 2.12)), although a generalised behavioural disorder was (OR 1.55 (95% CI 1.10 to 2.17)). Asthma significantly increased the risk of Perthes' disease (OR 1.44 (95% CI 1.17 to 1.76)), which remained after adjusting for oral/parenteral steroid use. Perthes' disease has a significant association with congenital genitourinary and inguinal anomalies, suggesting that intra-uterine factors may be critical to causation. Other comorbid associations may offer insight to support or refute theories of pathogenesis. |
| | |
Authors:
|
D C Perry; C E Bruce; D Pope; P Dangerfield; M J Platt; A J Hall |
Publication Detail:
|
Type: Journal Article |
Journal Detail:
|
Title: The Journal of bone and joint surgery. British volume Volume: 94 ISSN: 0301-620X ISO Abbreviation: J Bone Joint Surg Br Publication Date: 2012 Dec |
Date Detail:
|
Created Date: 2012-11-28 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 0375355 Medline TA: J Bone Joint Surg Br Country: England |
Other Details:
|
Languages: eng Pagination: 1684-9 Citation Subset: AIM; IM |
Affiliation:
|
Alder Hey Children's Hospital, Orthopaedic Department, Eaton Road, Liverpool L12 2AP, UK. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: The treatment of complex tibial shaft fractures by the Ilizarov method.
Next Document: Two Siblings With Similar Phenotypes: One of Them Had Ring 20 Chromosome.