| Comorbidities of chronic obstructive pulmonary disease. | |
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MedLine Citation:
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PMID: 22209926 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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PURPOSE OF REVIEW: Defining the nature of the association between chronic obstructive pulmonary disease (COPD) and other chronic conditions is of primary importance to improve the health status of COPD patients through the optimal care of comorbidities. We aimed at providing a reasoned guide to understand, recognize and treat comorbidity of COPD with the perspective of shifting from comorbidity to multimorbidity. RECENT FINDINGS: Select comorbidities, such as atherosclerotic disease, depression, chronic kidney disease, cognitive impairment, obstructive sleep apnea syndrome, lung cancer, osteoporosis, diabetes, heart failure, sarcopenia, aortic aneurysm, arrhythmias and pulmonary embolism are highly prevalent among older COPD patients. Several concerns may affect the management of older COPD patients with comorbidity (e.g. the use of β-blockers in patients with COPD and cardiovascular diseases or concerns about the cardiovascular safety of inhaled COPD drugs). SUMMARY: Evidence suggests that systemic inflammation may be the link between COPD and comorbidities, but this issue is still debated. Whatever the mechanism underlying comorbidities in COPD may be, it has an important clinical, prognostic and therapeutic impact. Nevertheless, clinical practice guidelines do not take into account comorbidities in their recommendations. Additionally, clinical trials investigating COPD treatment in the context of multimorbidity and considering geriatric outcomes are also distinctly lacking. |
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Authors:
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Andrea Corsonello; Raffaele Antonelli Incalzi; Riccardo Pistelli; Claudio Pedone; Silvia Bustacchini; Fabrizia Lattanzio |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Current opinion in pulmonary medicine Volume: 17 Suppl 1 ISSN: 1531-6971 ISO Abbreviation: Curr Opin Pulm Med Publication Date: 2011 Dec |
Date Detail:
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Created Date: 2012-01-02 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9503765 Medline TA: Curr Opin Pulm Med Country: United States |
Other Details:
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Languages: eng Pagination: S21-8 Citation Subset: IM |
Affiliation:
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aUnit of Geriatric Pharmacoepidemiology, Italian National Research Center on Aging (INRCA), Cosenza bChair of Geriatric Medicine, University Campus BioMedico, Rome cSan Raffaele Foundation, Cittadella della Carità, Taranto dCatholic University Hospital eAlberto Sordi Foundation, Rome fItalian National Research Center on Aging (INRCA), Ancona, Italy. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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