Document Detail

Comorbidities among HIV-infected injection drug users in Chennai, India.
MedLine Citation:
PMID:  18653907     Owner:  NLM     Status:  MEDLINE    
BACKGROUND & OBJECTIVE: HIV-infected injection drugs users (IDUs) are known to have high rates of co-infections. A few reports exist on comorbidities among HIV-infected IDUs in India. We carried out a retrospective study to analyse data on comorbidities in India and treatment challenges faced when treating HIV-infected IDUs in India.
METHODS: A retrospective chart review of 118 HIV-infected IDUs who accessed care at the YRG Centre for Substance Abuse-Related Research, Chennai, between August 2005 and February 2006 was done. Demographic, laboratory and clinical information was extracted from medical records. Descriptive demographic and clinical characteristics and distributions of comorbidities across CD4 cell count strata were analysed.
RESULTS: All IDUs were male with a median age of 35.5 yr. The majority were married with average monthly income less than INR 3000 per month. The prevalence of hepatitis B and C infections were 11.9 and 94.1 per cent, respectively. Other common co-morbidities included oral candidiasis (43.2%), tuberculosis (33.9%), anaemia (22.9%), lower respiratory tract infections (16.1%), cellulitis (6.8%), herpes zoster (9.3%) and herpes simplex (9.3%). Among participants with CD4+ < 200 cells/microl, the prevalence of TB was 60 per cent.
INTERPRETATION & CONCLUSION: IDUs in Chennai were commonly co-infected with HBV, HCV and tuberculosis, complicating use of antiretroviral and anti-tuberculous therapy. The current regimens available for the management of HIV and TB in India may need to be re-assessed for IDUs given the potential for increased rates of hepatotoxicity.
S S Solomon; C S Hawcroft; P Narasimhan; R Subbaraman; A K Srikrishnan; A J Cecelia; M Suresh Kumar; Suniti Solomon; J E Gallant; D D Celentano
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural    
Journal Detail:
Title:  The Indian journal of medical research     Volume:  127     ISSN:  0971-5916     ISO Abbreviation:  Indian J. Med. Res.     Publication Date:  2008 May 
Date Detail:
Created Date:  2008-07-25     Completed Date:  2008-11-10     Revised Date:  2014-03-25    
Medline Journal Info:
Nlm Unique ID:  0374701     Medline TA:  Indian J Med Res     Country:  India    
Other Details:
Languages:  eng     Pagination:  447-52     Citation Subset:  IM    
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MeSH Terms
HIV Infections* / epidemiology,  physiopathology,  therapy
Hepatitis B / epidemiology,  therapy
Hepatitis C / epidemiology,  therapy
India / epidemiology
Retrospective Studies
Substance Abuse, Intravenous / physiopathology,  virology*
Tuberculosis / epidemiology,  therapy
Grant Support
2D43 TW 000010/TW/FIC NIH HHS; 3D43 TW 000237-13S1/TW/FIC NIH HHS; D43 TW000237/TW/FIC NIH HHS
Comment In:
Indian J Med Res. 2008 May;127(5):428-30   [PMID:  18653904 ]

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