Document Detail


Comorbid psychiatric diagnoses and their association with cocaine-induced psychosis in cocaine-dependent subjects.
MedLine Citation:
PMID:  17882604     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Comorbidity between drug abuse and mental illness is very common, but the association of such comorbidity with specific responses to drugs of abuse remains obscure. The current study examined the relationship between the presence of non-psychotic Axis I psychiatric diagnoses and the frequency and severity of cocaine-induced psychosis. We interviewed 243 unrelated cocaine-dependent adults [37% European American (EA), 52.3% African American (AA); 58.8% male] using the Semi-Structured Assessment for Drug Dependence and Alcoholism (SSADDA) to establish DSM-IV diagnoses, and two instruments for the identification of cocaine-induced paranoia, the Cocaine Experience Questionnaire (CEQ) and the Scale for Assessment of Positive Symptoms for Cocaine-Induced Psychosis (SAPS-CIP). Comorbid substance use and psychiatric disorders were common in this cocaine-dependent sample. Ninety percent of subjects met criteria for substance use disorders other than cocaine dependence; common non-substance-use disorders included antisocial personality disorder (ASPD), adult ASPD, major depression, and attention deficit-hyperactivity disorder (ADHD). Comorbid opioid dependence was more common in EA subjects than in AA participants. After correction for multiple comparisons, a lifetime diagnosis of ADHD was associated with the categorical presence of CIP (p = 0.007), as well as significantly more severe CIP symptoms. Comorbid substance use and psychiatric disorders are very common among individuals with cocaine dependence. Comorbid ADHD increases the odds of an individual endorsing CIP, suggesting some common basis for these phenomena.
Authors:
Yi-Lang Tang; Henry R Kranzler; Joel Gelernter; Lindsay A Farrer; Joseph F Cubells
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.    
Journal Detail:
Title:  The American journal on addictions / American Academy of Psychiatrists in Alcoholism and Addictions     Volume:  16     ISSN:  1055-0496     ISO Abbreviation:  Am J Addict     Publication Date:    2007 Sep-Oct
Date Detail:
Created Date:  2007-09-20     Completed Date:  2008-01-29     Revised Date:  2012-10-12    
Medline Journal Info:
Nlm Unique ID:  9208821     Medline TA:  Am J Addict     Country:  United States    
Other Details:
Languages:  eng     Pagination:  343-51     Citation Subset:  IM    
Affiliation:
Department of Psychiatry, Yale University School of Medicine and VA Connecticut Health Care System, West Haven, CT, USA.
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MeSH Terms
Descriptor/Qualifier:
Adult
Alcoholism / epidemiology
Attention Deficit Disorder with Hyperactivity / epidemiology*
Cocaine / adverse effects*
Cocaine-Related Disorders / epidemiology*
Comorbidity
Demography
Diagnosis, Dual (Psychiatry)
Diagnostic and Statistical Manual of Mental Disorders
Female
Humans
Male
Mental Disorders / epidemiology*
Prevalence
Psychoses, Substance-Induced / epidemiology*,  etiology*
Smoking / epidemiology
Grant Support
ID/Acronym/Agency:
K02 DA 015766/DA/NIDA NIH HHS; K12 DA 00167/DA/NIDA NIH HHS; K24 AA 13736/AA/NIAAA NIH HHS; K24 DA 15105/DA/NIDA NIH HHS; K24 DA015105/DA/NIDA NIH HHS; R01 DA 12422/DA/NIDA NIH HHS; R01 DA 12690/DA/NIDA NIH HHS; R01 DA 12849/DA/NIDA NIH HHS; R01 DA012690/DA/NIDA NIH HHS; R01 DA012849/DA/NIDA NIH HHS
Chemical
Reg. No./Substance:
50-36-2/Cocaine
Comments/Corrections
Comment In:
Am J Addict. 2008 May-Jun;17(3):247-8; author reply 249-50   [PMID:  18464004 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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