| Comorbid conditions and survival in unselected, newly diagnosed patients with chronic lymphocytic leukemia. | |
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MedLine Citation:
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PMID: 18203011 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Little is known about the spectrum or frequency of comorbidities in patients with chronic lymphocytic leukemia (CLL). We investigated the prevalence and prognostic implications of comorbidities in patients with newly diagnosed CLL. Local/non-referred patients with CLL evaluated by a hematologist at Mayo Clinic within 1 year of diagnosis were eligible for this retrospective review. Of 1195 individuals evaluated for newly-diagnosed CLL between 1995 and 2006, 373 (31%) were local/non-referred. At diagnosis, 89% of these patients had one or more comorbidities, and 46% had at least one major comorbidity. Twenty-six percent of patients failed to meet NCI working group guidelines to participate in a clinical trial. On multi-factor analysis, Rai risk category (1.39 per each risk category increase; p < 0.0001) and age (1.056 per year increase; p < 0.0001) were the only factors associated with overall survival. We conclude that, although common, comorbid conditions are less important than age and stage in predicting prognosis in newly diagnosed patients with CLL. Clinical trials evaluating treatments that are designed to be tolerated by patients who do not meet traditional clinical trial eligibility criteria are needed. |
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Authors:
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Paul Thurmes; Timothy Call; Susan Slager; Clive Zent; Gregory Jenkins; Susan Schwager; Deborah Bowen; Neil Kay; Tait Shanafelt |
Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Leukemia & lymphoma Volume: 49 ISSN: 1029-2403 ISO Abbreviation: Leuk. Lymphoma Publication Date: 2008 Jan |
Date Detail:
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Created Date: 2008-01-18 Completed Date: 2008-04-16 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9007422 Medline TA: Leuk Lymphoma Country: England |
Other Details:
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Languages: eng Pagination: 49-56 Citation Subset: IM |
Affiliation:
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Mayo Clinic College of Medicine, Rochester, MN 55905, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Aged Comorbidity* Databases, Factual Female Humans Leukemia, Lymphocytic, Chronic, B-Cell / diagnosis, mortality* Male Middle Aged Prognosis Retrospective Studies Survival Analysis Survival Rate |
| Grant Support | |
ID/Acronym/Agency:
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CA 113408/CA/NCI NIH HHS; CA 94919/CA/NCI NIH HHS; CA97274/CA/NCI NIH HHS |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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