Document Detail

Comorbid anxious signs and symptoms in major depression: impact on functional work capacity and comparative treatment outcomes.
MedLine Citation:
PMID:  8277149     Owner:  NLM     Status:  MEDLINE    
Psychological distress is a driver both of direct and indirect health care costs. Depression compromises functional well-being, such as work productivity. Comorbid anxious features often complicate the recognition of depression and may herald a poor prognosis. We report the results of a cross-sectional naturalistic study to determine the impact of three interventions (no antidepressant, fluoxetine, or tricyclic antidepressant therapy) on relative risk of work days lost in 454 French outpatients with either major or minor depression. Most depressed patients also manifested anxious features (76% with a Hamilton Rating Scale for Anxiety score > or = 12). The presence of anxiety was related to the severity of depression, work absenteeism, and current social instability. Depression severity (Hamilton Rating Scale for Depression score > or = 26, including the contributions of anxious symptoms), psychiatric comorbidity, and psychomotor retardation best predicted continued work absenteeism. Patients with major depression were more likely to receive an antidepressant if they had a past history of depressive episodes and/or previous work disability. Patients with minor depression were less likely to receive drug therapy than patients with major depression, despite their current work disability. Among patients who received fluoxetine or a tricyclic antidepressant for at least 8 weeks, fluoxetine was associated with statistically significantly lower mean anxiety and depression scores and fewer work days missed.
G D Tollefson; E Souetre; L Thomander; J H Potvin
Related Documents :
10796719 - St john's wort for depression.
20530589 - Transient inactivation of the infralimbic cortex induces antidepressant-like effects in...
17205639 - The expert consensus guideline series. pharmacotherapy of depressive disorders in older...
17447229 - Are there predictors of outcome in depressed elderly nursing home residents during trea...
3973069 - The use of antidepressants in a psychiatric emergency department.
16208839 - Modafinil augmentation in depressed patients with partial response to antidepressants: ...
18622369 - Initial effectiveness, partial remission, and full remission in depression: focus on lo...
10750629 - Effects of melatonin on the quality of life in patients with delayed sleep phase syndrome.
7011469 - Controlled trial of sulpiride in chronic schizophrenic patients.
Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  International clinical psychopharmacology     Volume:  8     ISSN:  0268-1315     ISO Abbreviation:  Int Clin Psychopharmacol     Publication Date:  1993  
Date Detail:
Created Date:  1994-02-04     Completed Date:  1994-02-04     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8609061     Medline TA:  Int Clin Psychopharmacol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  281-93     Citation Subset:  IM    
Psychopharmacology Division, Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, Indiana 46285.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Amitriptyline / administration & dosage,  adverse effects
Antidepressive Agents, Tricyclic / administration & dosage*,  adverse effects
Anxiety / diagnosis,  drug therapy*,  psychology
Clomipramine / administration & dosage,  adverse effects
Cost of Illness
Cross-Sectional Studies
Depressive Disorder / diagnosis,  drug therapy*,  psychology
Dose-Response Relationship, Drug
Fluoxetine / administration & dosage*,  adverse effects
Middle Aged
Personality Inventory
Work Capacity Evaluation*
Reg. No./Substance:
0/Antidepressive Agents, Tricyclic; 303-49-1/Clomipramine; 50-48-6/Amitriptyline; 54910-89-3/Fluoxetine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Fluoxetine not associated with increased aggression in controlled clinical trials.
Next Document:  Pharmacotherapy of bulimia nervosa--experience with fluoxetine.