Document Detail

Community-based screening for Down's Syndrome in the first trimester using ultrasound and maternal serum biochemistry.
MedLine Citation:
PMID:  16225579     Owner:  NLM     Status:  MEDLINE    
Two years of community-based first trimester screening (FTS) were audited. All women with singleton pregnancy in a defined health region who completed FTS (ultrasound and biochemistry) were included (n= 10,436) and outcomes obtained for 98.4%. All scans were performed or supervised by experienced sonologists with Fetal Medicine Foundation (FMF) accreditation. FMF software generated all risk assessments based on nuchal translucency (NT), maternal serum-free beta human chorionic gonadotropin (beta-hCG) and pregnancy-associated plasma protein A (PAPP-A). The detection rate for Trisomy 21 was 90.6% with a screen-positive rate of 3.9%. These findings indicate that where FTS is accessible within routine antenatal care, a detection rate of 90% and low screen-positive rate can be achieved using the FMF programme.
Narelle C Hadlow; Beverley G Hewitt; Jan E Dickinson; Peter Jacoby; Carol Bower
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Publication Detail:
Type:  Journal Article; Multicenter Study; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  BJOG : an international journal of obstetrics and gynaecology     Volume:  112     ISSN:  1470-0328     ISO Abbreviation:  BJOG     Publication Date:  2005 Nov 
Date Detail:
Created Date:  2005-10-17     Completed Date:  2005-12-13     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  100935741     Medline TA:  BJOG     Country:  England    
Other Details:
Languages:  eng     Pagination:  1561-4     Citation Subset:  AIM; IM    
Western Diagnostic Pathology, Mayne Health, Western Australia, Australia.
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MeSH Terms
Chorionic Gonadotropin, beta Subunit, Human / blood*
Colposcopy / methods
Community Health Services
Down Syndrome / blood,  diagnosis*,  ultrasonography
False Positive Reactions
Nuchal Translucency Measurement
Pregnancy Trimester, First
Pregnancy-Associated Plasma Protein-A / analysis*
Prenatal Diagnosis / methods*
Risk Assessment
Sensitivity and Specificity
Vaginal Smears / methods
Reg. No./Substance:
0/Chorionic Gonadotropin, beta Subunit, Human; EC 3.4.24.-/Pregnancy-Associated Plasma Protein-A
Comment In:
BJOG. 2006 Mar;113(3):362; author reply 363-4   [PMID:  16487214 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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