| Community-based screening for Down's Syndrome in the first trimester using ultrasound and maternal serum biochemistry. | |
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MedLine Citation:
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PMID: 16225579 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Two years of community-based first trimester screening (FTS) were audited. All women with singleton pregnancy in a defined health region who completed FTS (ultrasound and biochemistry) were included (n= 10,436) and outcomes obtained for 98.4%. All scans were performed or supervised by experienced sonologists with Fetal Medicine Foundation (FMF) accreditation. FMF software generated all risk assessments based on nuchal translucency (NT), maternal serum-free beta human chorionic gonadotropin (beta-hCG) and pregnancy-associated plasma protein A (PAPP-A). The detection rate for Trisomy 21 was 90.6% with a screen-positive rate of 3.9%. These findings indicate that where FTS is accessible within routine antenatal care, a detection rate of 90% and low screen-positive rate can be achieved using the FMF programme. |
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Authors:
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Narelle C Hadlow; Beverley G Hewitt; Jan E Dickinson; Peter Jacoby; Carol Bower |
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Publication Detail:
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Type: Journal Article; Multicenter Study; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: BJOG : an international journal of obstetrics and gynaecology Volume: 112 ISSN: 1470-0328 ISO Abbreviation: BJOG Publication Date: 2005 Nov |
Date Detail:
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Created Date: 2005-10-17 Completed Date: 2005-12-13 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 100935741 Medline TA: BJOG Country: England |
Other Details:
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Languages: eng Pagination: 1561-4 Citation Subset: AIM; IM |
Affiliation:
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Western Diagnostic Pathology, Mayne Health, Western Australia, Australia. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Chorionic Gonadotropin, beta Subunit, Human / blood* Colposcopy / methods Community Health Services Down Syndrome / blood, diagnosis*, ultrasonography False Positive Reactions Female Humans Karyotyping Nuchal Translucency Measurement Pregnancy Pregnancy Trimester, First Pregnancy-Associated Plasma Protein-A / analysis* Prenatal Diagnosis / methods* Risk Assessment Sensitivity and Specificity Vaginal Smears / methods |
| Chemical | |
Reg. No./Substance:
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0/Chorionic Gonadotropin, beta Subunit, Human; EC 3.4.24.-/Pregnancy-Associated Plasma Protein-A |
| Comments/Corrections | |
Comment In:
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BJOG. 2006 Mar;113(3):362; author reply 363-4
[PMID:
16487214
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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