Document Detail

Community based lifestyle intervention for blood pressure reduction in children and young adults in developing country: cluster randomised controlled trial.
MedLine Citation:
PMID:  20530082     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To assess the effectiveness of a community based lifestyle intervention on blood pressure in children and young adults in a developing country setting.
DESIGN: Cluster randomised controlled trial.
SETTING: 12 randomly selected geographical census based clusters in Karachi, Pakistan.
PARTICIPANTS: 4023 people aged 5-39 years.
INTERVENTION: Three monthly family based home health education delivered by lay health workers.
MAIN OUTCOME MEASURE: Change in blood pressure from randomisation to end of follow-up at 2 years.
RESULTS: Analysed using the intention to treat principle, the change in systolic blood pressure (adjusted for age, sex, and baseline blood pressure) was significant; it increased by 1.5 (95% confidence interval 1.1 to 1.9) mm Hg in the control group and by 0.1 (-0.3 to 0.5) mm Hg in the home health education group (P for difference between groups=0.02). Findings for diastolic blood pressure were similar; the change was 1.5 mm Hg greater in the control group than in the intervention group (P=0.002).
CONCLUSIONS: Simple, family based home health education delivered by trained lay health workers significantly ameliorated the usual increase in blood pressure with age in children and young adults in the general population of Pakistan, a low income developing country. This strategy is potentially feasible for up-scaling within the existing healthcare systems of Indo-Asia.
TRIAL REGISTRATION: Clinical trials NCT00327574.
Tazeen H Jafar; Muhammad Islam; Juanita Hatcher; Shiraz Hashmi; Rasool Bux; Ayesha Khan; Neil Poulter; Salma Badruddin; Nish Chaturvedi;
Publication Detail:
Type:  Journal Article; Multicenter Study; Randomized Controlled Trial; Research Support, Non-U.S. Gov't     Date:  2010-06-07
Journal Detail:
Title:  BMJ (Clinical research ed.)     Volume:  340     ISSN:  1756-1833     ISO Abbreviation:  BMJ     Publication Date:  2010  
Date Detail:
Created Date:  2010-06-09     Completed Date:  2010-06-22     Revised Date:  2013-05-29    
Medline Journal Info:
Nlm Unique ID:  8900488     Medline TA:  BMJ     Country:  England    
Other Details:
Languages:  eng     Pagination:  c2641     Citation Subset:  AIM; IM    
Department of Medicine, Aga Khan University, Karachi, Pakistan.
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MeSH Terms
Blood Pressure / physiology
Child, Preschool
Cluster Analysis
Community Health Workers
Developing Countries*
Health Education / methods*
Home Care Services*
Hypertension / physiopathology,  prevention & control*
Life Style*
Young Adult
Grant Support
070854/Z/03/Z//Wellcome Trust
Fahim Jafary / ; Aamir Hameed / ; Ata Khan / ; Anwar Gilani / ; Shehla Zaidi / ; Nadir Syed / ; Saleem Jessani / ; Zeeshan Qadri / ; Peter Cosgrove /

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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