Document Detail

Communication Signals Between Cardiac Fibroblasts and Cardiac Myocytes.
MedLine Citation:
PMID:  21297490     Owner:  NLM     Status:  Publisher    
Interspersed between cardiac myocytes, cardiac fibroblasts serve mainly as a structural support during ventricular wall thickening from embryogenesis until adulthood. Cardiac fibroblasts, however, may also serve as a source of mitogens, extracellular matrix proteins, cytokines, and growth factors that could affect the phenotype of the cardiac myocyte. The crosstalk between cardiac fibroblasts and myocytes are important during cardiac development and remodeling in response to injury. The cell-to cell communication involves paracrine signals (cytokines and growth factors), direct interactions (connexins and cadherins), as well as, indirect interactions (integrin signaling through the extracellular matrix). In this review, known cardiac fibroblast-cardiac myocyte signaling pathways will be briefly examined and their effect on the heart during disease progression will be discussed. Furthermore, speculations will be made regarding the possibility that vascular endothelial growth factor B can serve as an important signaling molecule between cardiac fibroblasts and cardiac myocytes, and could promote cardiac function in compromised hearts.
Filomena G Ottaviano; Karen O Yee
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-2-03
Journal Detail:
Title:  Journal of cardiovascular pharmacology     Volume:  -     ISSN:  1533-4023     ISO Abbreviation:  -     Publication Date:  2011 Feb 
Date Detail:
Created Date:  2011-2-7     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7902492     Medline TA:  J Cardiovasc Pharmacol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Beth Israel Deaconess Medical Center/ Harvard Medical School, 330 Brookline Ave, Boston MA 02115.
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