Document Detail

Common variants in mismatch repair genes and risk of invasive ovarian cancer.
MedLine Citation:
PMID:  16774946     Owner:  NLM     Status:  MEDLINE    
Mismatch repair (MMR) is important for repairing of nucleotide mismatches during DNA replication. Germline mutations in MMR genes are associated with hereditary non-polyposis colorectal cancer (HNPCC). Ovarian cancer occurs as part of the HNPCC phenotype, and so common variants in MMR genes are candidates for ovarian cancer susceptibility. We performed a large multicentre case-control study to investigate associations of common variations in MMR genes and ovarian cancer using a single nucleotide polymorphism (SNP) tagging approach. A total of 2570 controls and 1531 cases from three separate studies were genotyped for 44 tagging SNPs (stSNP) in seven MMR genes (MLH1, MLH3, MSH2, MSH3, MSH6, PMS1 and PMS2). Genotype frequencies were marginally different between cases and controls for PMS2 rs7797466 (P(2df) = 0.046) with a 1.17-fold (95% CI 1.03-1.33) increase in risk for each 'a' allele carried (P-trend = 0.013). Haplotype analysis of PMS2 also showed significant differences in frequencies between cases and controls (P(7df) = 0.005), with one haplotype accounting for most of the effect. There was also marginal evidence for a recessive protective effect with common homozygote as the baseline comparator for two SNPs--MSH6 rs3136245 (OR 0.67; 95% CI 0.46-0.98) and MSH3 rs6151662 (OR 0.28; 95% CI 0.08-0.91)--but the comparisons of genotype frequencies for these variants were not significant (P = 0.10 and 0.054). In conclusion, it is unlikely that common variants in MLH1, MLH3, PMS1, MSH2, MSH3 and MSH6 contribute significantly to ovarian cancer susceptibility. The observed association of PMS2 rs7797466 with ovarian cancer warrants confirmation in an independent study.
Honglin Song; Susan J Ramus; Lydia Quaye; Richard A DiCioccio; Jonathan Tyrer; Emma Lomas; Danielle Shadforth; Estrid Hogdall; Claus Hogdall; Valerie McGuire; Alice S Whittemore; Douglas F Easton; Bruce A J Ponder; Susanne Kruger Kjaer; Paul D P Pharoah; Simon A Gayther
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Publication Detail:
Type:  Journal Article; Multicenter Study; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't     Date:  2006-06-13
Journal Detail:
Title:  Carcinogenesis     Volume:  27     ISSN:  0143-3334     ISO Abbreviation:  Carcinogenesis     Publication Date:  2006 Nov 
Date Detail:
Created Date:  2006-10-27     Completed Date:  2006-12-26     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  8008055     Medline TA:  Carcinogenesis     Country:  England    
Other Details:
Languages:  eng     Pagination:  2235-42     Citation Subset:  IM    
CR-UK Department of Oncology, University of Cambridge Strangeways Research Laboratory, Cambridge, UK.
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MeSH Terms
Adenosine Triphosphatases / genetics*
Aged, 80 and over
Case-Control Studies
DNA Repair*
DNA Repair Enzymes / genetics*
DNA-Binding Proteins / genetics*
Genetic Predisposition to Disease*
Genetic Variation*
Middle Aged
Nuclear Proteins / genetics*
Ovarian Neoplasms / genetics*
Polymorphism, Single Nucleotide
Grant Support
Reg. No./Substance:
0/DNA-Binding Proteins; 0/Nuclear Proteins; EC 3.6.1.-/Adenosine Triphosphatases; EC 3.6.1.-/PMS2 protein, human; EC 6.5.1.-/DNA Repair Enzymes

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