| Common variants in genes underlying monogenic hypertension and hypotension and blood pressure in the general population. | |
| | |
MedLine Citation:
|
PMID: 18443236 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
The genes responsible for several monogenic hypertensive and hypotensive disorders have been identified. Our aim was to evaluate whether common variants in these genes affect blood pressure in the general population. We studied 2037 adults from 520 nuclear families characterized for 24-hour ambulatory blood pressure and related cardiovascular traits. We genotyped 298 tagging and putative functional single nucleotide polymorphisms, achieving a median coverage of 82.4% across 11 candidate loci. Five polymorphisms in the KCNJ1 gene coding for the potassium channel, ROMK, showed associations with mean 24-hour systolic or diastolic blood pressure. The strongest association was with an intronic polymorphism, rs2846679, where the minor allele (frequency 16%) was associated with a -1.58 (95% CI -2.47 to -0.69) mm Hg change in mean 24-hour systolic blood pressure, after accounting for age, sex, and familial correlations (P=0.00048). Polymorphisms in the gene were also associated with clinic blood pressure and left ventricular mass as assessed by ECG Sokolow-Lyon voltage (P=0.0081 for rs675759). Associations with mean 24-hour systolic or diastolic blood pressure were also observed for variants in CASR, NR3C2, SCNN1B, and SCNN1G. The findings show that common variants in genes responsible for some Mendelian disorders of hypertension and hypotension affect blood pressure in the general population. Notably, variants in KCNJ1, which causes Bartter syndrome type 2, were strongly associated, potentially providing a novel target for intervention. |
| | |
Authors:
|
Martin D Tobin; Maciej Tomaszewski; Peter S Braund; Cother Hajat; Stuart M Raleigh; Thomas M Palmer; Mark Caulfield; Paul R Burton; Nilesh J Samani |
Related Documents
:
|
9745096 - Maternal brachial arterial waveforms in gestational hypertension: analysis using a lapl... 7758176 - Angiotensin-converting enzyme i/d polymorphism and arterial wall thickness in a general... 9498106 - Association of angiotensin ii type 1 receptor polymorphism with resistant essential hyp... 16818806 - A quantitative trait loci-specific gene-by-sex interaction on systolic blood pressure a... 16116336 - Lowering of elevated ambulatory blood pressure by hmg-coa reductase inhibitors. 11416656 - The relationship between body weight and the prevalence of isolated systolic hypertensi... |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2008-04-28 |
Journal Detail:
|
Title: Hypertension Volume: 51 ISSN: 1524-4563 ISO Abbreviation: Hypertension Publication Date: 2008 Jun |
Date Detail:
|
Created Date: 2008-05-23 Completed Date: 2008-06-30 Revised Date: 2008-11-21 |
Medline Journal Info:
|
Nlm Unique ID: 7906255 Medline TA: Hypertension Country: United States |
Other Details:
|
Languages: eng Pagination: 1658-64 Citation Subset: IM |
Affiliation:
|
Department of Health Sciences & Genetics, University of Leicester, UK. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adolescent Adult Blood Pressure / genetics Epithelial Sodium Channel / genetics Family Health Female Genetic Predisposition to Disease / epidemiology Genetic Variation* Genotype Humans Hypertension / epidemiology, genetics* Hypotension / epidemiology, genetics* Male Middle Aged Polymorphism, Single Nucleotide Potassium Channels, Inwardly Rectifying / genetics* Receptors, Calcium-Sensing / genetics Receptors, Mineralocorticoid / genetics Risk Factors |
| Grant Support | |
ID/Acronym/Agency:
|
G0501942//Medical Research Council; //British Heart Foundation; //Wellcome Trust |
| Chemical | |
Reg. No./Substance:
|
0/CASR protein, human; 0/Epithelial Sodium Channel; 0/KCNJ1 protein, human; 0/Potassium Channels, Inwardly Rectifying; 0/Receptors, Calcium-Sensing; 0/Receptors, Mineralocorticoid; 0/SCNN1B protein, human; 0/SCNN1G protein, human |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Relation of blood pressure and all-cause mortality in 180,000 Japanese participants: pooled analysis...
Next Document: Both intestinal and hepatic lipoprotein production are stimulated by an acute elevation of plasma fr...