Document Detail

Common variants in the ATP2B1 gene are associated with hypertension and arterial stiffness in Chinese population.
MedLine Citation:
PMID:  23079715     Owner:  NLM     Status:  Publisher    
Genome-wide association studies have identified the ATP2B1 gene associated with blood pressure (BP), the evidence from large scale Chinese population was still rare. We performed the current replication study to test the association of the ATP2B1 gene and hypertension and BP in two unrelated Chinese cohorts including 2,831 unrelated individuals with hypertension and 1,987 controls in total. We also examined the influences of the ATP2B1 gene on the arterial stiffness through evaluation of carotid-femoral pulse wave velocities (cf-PWV) in 164 untreated hypertensives. The major findings of this study were that four loci--rs10858911, rs2681472, rs17249754 and rs1401982--associated with any or all of four traits: hypertension (P = 0.001-4.6E-05; odds ratio, 0.83-0.87), systolic BP (P = 0.003-0.004), diastolic BP (P = 0.002-0.003) and cf-PWV (P = 0.002-0.004). All the comparisons were adjusted for sex, age, age(2) and body mass index. We validated the association of the ATP2B1 gene and susceptibility to hypertension, BP traits and cf-PWV in Chinese population. In addition, further genetic and functional research was warranted to elucidate the concrete locus in the ATP2B1 gene that influenced the manifestation of BP and vascular function.
Yan Wang; Yi Zhang; Yan Li; Xueya Zhou; Xiaofeng Wang; Pingjin Gao; Li Jin; Xuegong Zhang; Dingliang Zhu
Related Documents :
23366585 - Early detection of hemorrhage via central pulse pressure derived from a non-invasive pe...
12651175 - Aortic side branch perfusion alone does not account for high intra-sac pressure after e...
12527675 - Exercise systolic blood pressures are of questionable value in the assessment of the ad...
22615185 - A comparison of different bedside techniques to determine endotracheal tube position in...
16461835 - Artificial baroreflex: clinical application of a bionic baroreflex system.
24966435 - Studies on the effect of preservatives on physico-chemical, microbiological and sensory...
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-10-19
Journal Detail:
Title:  Molecular biology reports     Volume:  -     ISSN:  1573-4978     ISO Abbreviation:  Mol. Biol. Rep.     Publication Date:  2012 Oct 
Date Detail:
Created Date:  2012-10-19     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0403234     Medline TA:  Mol Biol Rep     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
State Key Laboratory of Medical Genomics, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  The genetic polymorphisms of intercellular cell adhesion molecules and breast cancer susceptibility:...
Next Document:  Overexpression of human SPATA17 protein induces germ cell apoptosis in transgenic male mice.