| Common variants of homocysteine metabolism pathway genes and risk of type 2 diabetes and related traits in Indians. | |
| | |
MedLine Citation:
|
PMID: 21960995 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Hyperhomocysteinemia, a risk factor for cardiovascular disorder, obesity, and type 2 diabetes, is prevalent among Indians who are at high risk of these metabolic disorders. We evaluated association of common variants of genes involved in homocysteine metabolism or its levels with type 2 diabetes, obesity, and related traits in North Indians. We genotyped 90 variants in initial phase (2.115 subjects) and replicated top signals in an independent sample set (2.085 subjects). The variant MTHFR-rs1801133 was the top signal for association with type 2 diabetes (OR = 0.78 (95% CI = 0.67-0.92), P = 0.003) and was also associated with 2 h postload plasma glucose (P = 0.04), high-density lipoprotein cholesterol (P = 0.004), and total cholesterol (P = 0.01) in control subjects. These associations were neither replicated nor significant after meta-analysis. Studies involving a larger study population and different ethnic groups are required before ruling out the role of these important candidate genes in type 2 diabetes, obesity, and related traits. |
| | |
Authors:
|
Ganesh Chauhan; Ismeet Kaur; Rubina Tabassum; Om Prakash Dwivedi; Saurabh Ghosh; Nikhil Tandon; Dwaipayan Bharadwaj |
Related Documents
:
|
6996505 - Immunoreactive glucagon and insulin c-peptide in man after resection of the pancreas an... 6291325 - Metabolic and hormonal adjustments during hemorrhage in cats after interference with th... 7044765 - Circadian stage-dependent effects of insulin and glucagon on incorporation of [3h]thymi... 6132675 - A possible role for somatostatin in depression of insulin and glucagon levels during he... 17213275 - Plasma concentration of pigment epithelium-derived factor in patients with diabetic ret... 1798855 - Small bowel and colon glucose absorption study in rats by an adaptation of sols and pon... |
Publication Detail:
|
Type: Journal Article; Meta-Analysis; Research Support, Non-U.S. Gov't Date: 2011-09-25 |
Journal Detail:
|
Title: Experimental diabetes research Volume: 2012 ISSN: 1687-5303 ISO Abbreviation: Exp Diabetes Res Publication Date: 2012 |
Date Detail:
|
Created Date: 2011-09-30 Completed Date: 2012-01-16 Revised Date: 2012-05-07 |
Medline Journal Info:
|
Nlm Unique ID: 101274844 Medline TA: Exp Diabetes Res Country: United States |
Other Details:
|
Languages: eng Pagination: 960318 Citation Subset: IM |
Affiliation:
|
Genomics and Molecular Medicine Unit, CSIR-Institute of Genomics and Integrative Biology, New Delhi, India. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adult Blood Glucose / metabolism Case-Control Studies Cholesterol / blood Cholesterol, HDL / blood Diabetes Mellitus, Type 2 / blood, genetics*, metabolism* Female Genetic Association Studies Genetic Variation Homocysteine / metabolism* Humans India Male Metabolic Networks and Pathways / genetics Methylenetetrahydrofolate Reductase (NADPH2) / genetics Middle Aged Polymorphism, Single Nucleotide Risk Factors |
| Chemical | |
Reg. No./Substance:
|
0/Blood Glucose; 0/Cholesterol, HDL; 454-28-4/Homocysteine; 57-88-5/Cholesterol; EC 1.5.1.20/Methylenetetrahydrofolate Reductase (NADPH2) |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Short-chain fatty acid propionate alleviates Akt2 knockout-induced myocardial contractile dysfunctio...
Next Document: On the Use of EEG or MEG Brain Imaging Tools in Neuromarketing Research.