| Common variants of FTO and the risk of obesity and type 2 diabetes in Indians. | |
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MedLine Citation:
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PMID: 21814223 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Common variants of fat mass and obesity-associated gene (FTO, fat mass- and obesity-associated gene) have been shown to be associated with obesity and type 2 diabetes in population of European and non-European ethnicity. However, studies in Indian population have provided inconsistent results. Here, we examined association of eight FTO variants (rs1421085, rs8050136, rs9939609, rs9930506, rs1861867, rs9926180, rs2540769 and rs708277) with obesity and type 2 diabetes in 5364 North Indians (2474 type 2 diabetes patients and 2890 non-diabetic controls) in two stages. None of the variants including previously reported intron 1 variants (rs1421085, rs8050136, rs9939609 and rs9930506) showed body mass index (BMI)-dependent/independent association with type 2 diabetes. However, rs1421085, rs8050136 and rs9939609 were associated with obesity status and measures of obesity (BMI, waist circumference and waist-to-hip ratio) in stage 2 and combined study population. Meta-analysis of the two study population results also revealed that rs1421085, rs8050136 and rs9939609 were significantly associated with BMI both under the random- and fixed-effect models (P (random/fixed)=0.02/0.0001, 0.004/0.0006 and 0.01/0.01, respectively). In conclusion, common variants of FTO were associated with obesity, but not with type 2 diabetes in North Indian population.Journal of Human Genetics advance online publication, 4 August 2011; doi:10.1038/jhg.2011.87. |
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Authors:
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Ganesh Chauhan; Rubina Tabassum; Anubha Mahajan; Om Prakash Dwivedi; Yuvaraj Mahendran; Ismeet Kaur; Shubhanchi Nigam; Himanshu Dubey; Binuja Varma; Sri Venkata Madhu; Sandeep K Mathur; Saurabh Ghosh; Nikhil Tandon; Dwaipayan Bharadwaj |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-8-04 |
Journal Detail:
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Title: Journal of human genetics Volume: - ISSN: 1435-232X ISO Abbreviation: - Publication Date: 2011 Aug |
Date Detail:
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Created Date: 2011-8-4 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9808008 Medline TA: J Hum Genet Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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Genomics and Molecular Medicine Unit, Institute of Genomics and Integrative Biology (CSIR), Delhi, India. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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