Document Detail

Common rules guide comparisons of speed and direction of motion in the dorsolateral prefrontal cortex.
MedLine Citation:
PMID:  23325236     Owner:  NLM     Status:  MEDLINE    
When a monkey needs to decide whether motion direction of one stimulus is the same or different as that of another held in working memory, neurons in dorsolateral prefrontal cortex (DLPFC) faithfully represent the motion directions being evaluated and contribute to their comparison. Here, we examined whether DLPFC neurons are more generally involved in other types of sensory comparisons. Such involvement would support the existence of generalized sensory comparison mechanisms within DLPFC, shedding light on top-down influences this region is likely to provide to the upstream sensory neurons during comparison tasks. We recorded activity of individual neurons in the DLPFC while monkeys performed a memory-guided decision task in which the important dimension was the speed of two sequentially presented moving random-dot stimuli. We found that many neurons, both narrow-spiking putative local interneurons and broad-spiking putative pyramidal output cells, were speed-selective, with tuning reminiscent of that observed in the motion processing middle temporal (MT) cortical area. Throughout the delay, broad-spiking neurons were more active, showing anticipatory rate modulation and transient periods of speed selectivity. During the comparison stimulus, responses of both cell types were modulated by the speed of the first stimulus, and their activity was highly predictive of the animals' behavioral report. These results are similar to those found for comparisons of motion direction, suggesting the existence of generalized neural mechanisms in the DLPFC subserving the comparison of sensory signals.
Cory R Hussar; Tatiana Pasternak
Related Documents :
23637166 - Primary hippocampal neurons, which lack four crucial extracellular matrix molecules, di...
23108546 - Hub and switches: endocannabinoid signalling in midbrain dopamine neurons.
24218086 - Amp-activated protein kinase (ampk) mediates activity-dependent axon branching by recru...
24662146 - Histopathology of motor cortex in an experimental focal ischemic stroke in mouse model.
18443376 - Nsaid loxoprofen inhibits high threshold or wide dynamic range neuronal responses in th...
11723396 - Prospective study of trigeminal sensibility after whiplash trauma.
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural    
Journal Detail:
Title:  The Journal of neuroscience : the official journal of the Society for Neuroscience     Volume:  33     ISSN:  1529-2401     ISO Abbreviation:  J. Neurosci.     Publication Date:  2013 Jan 
Date Detail:
Created Date:  2013-01-17     Completed Date:  2013-04-01     Revised Date:  2013-07-18    
Medline Journal Info:
Nlm Unique ID:  8102140     Medline TA:  J Neurosci     Country:  United States    
Other Details:
Languages:  eng     Pagination:  972-86     Citation Subset:  IM    
Department of Neurobiology and Anatomy, University of Rochester, Rochester, New York 14642, USA.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Action Potentials / physiology*
Discrimination (Psychology) / physiology
Memory, Short-Term / physiology
Motion Perception / physiology*
Neurons / physiology*
Orientation / physiology
Photic Stimulation
Prefrontal Cortex / physiology*
Psychomotor Performance / physiology
Reaction Time / physiology
Grant Support
P30 EY001319/EY/NEI NIH HHS; P30 EY01319/EY/NEI NIH HHS; R01 EY011749/EY/NEI NIH HHS; R01 EY11749/EY/NEI NIH HHS; T32 EY007125/EY/NEI NIH HHS

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Adolescent morphine exposure affects long-term microglial function and later-life relapse liability ...
Next Document:  Layer III Neurons Control Synchronized Waves in the Immature Cerebral Cortex.